锌补充剂摄入与生物衰老的双向关联通过代谢当量的任务相互作用：一项大规模的基于人群的生物银行研究

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition Pub Date : 2025-05-02 DOI:10.1016/j.clnu.2025.04.029

Yang Zhou , Jiayan Zhou , Zhao Li , Jingyi Wang , Hongzheng Li , Xiangjun Yin , Jialiang Gao , Ying Wu , Jinlin Li , Ya Xuan Sun , Yige Li , Weiguang Wang , Pinar O. Eser , Themistocles L. Assimes , Jie He , Guang Chen

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引用次数: 0

摘要

背景：锌摄入与生物衰老之间的关系以及体育锻炼是否能改变这种关系仍不确定。我们的目的是探讨锌摄入量与生物衰老之间的相关性，并评估体育锻炼的调节作用。方法从生物银行68947名参与者中提取数据。使用标准方程计算每日锌摄入量和生物年龄，并通过每周任务代谢当量（MET）测量体育锻炼。采用广义线性回归模型，调整混杂因素，探讨锌摄入量与生物衰老之间的关系。分别进行预先指定的亚组和敏感性分析，以确定MET的效果修改并验证研究结果的稳健性。结果回归模型显示，推荐剂量的锌摄入与生物年龄延迟0.13年相关[95%置信区间(CI) = - 0.21 ~ - 0.05]，而过量摄入锌（每天40 mg）与生物年龄延迟3.23年相关（95% CI = 0.18 ~ 6.28）。与锌摄入量不足和体育锻炼不足的参与者相比，坚持推荐的锌摄入量并进行足够的体育锻炼（每周600 MET）的参与者显示，加速生物衰老的可能性降低了31%(优势比= 0.69,95% CI = 0.66至0.74,p <；0.001)。亚组分析表明，在税前家庭年收入低于30,999英镑的低收入人群中，锌摄入量与延迟的生物衰老之间的关联更为明显（P-interaction <0.001）。敏感性分析证实了这些结果的稳健性。结论推荐剂量的锌摄入与延缓生物衰老有关，每周超过600 MET的体育锻炼增强了这种关联。相反，过量的锌摄入与加速生物衰老有关。我们建议人们每天谨慎服用锌补充剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Bidirectional associations of zinc supplement intake with biological ageing interacted by metabolic equivalent of task: A large-scale population-based Biobank study

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Bidirectional associations of zinc supplement intake with biological ageing interacted by metabolic equivalent of task: A large-scale population-based Biobank study

Background

The association of zinc intake with biological ageing and whether physical exercise modifies this association remain uncertain. We aimed to explore the correlations between zinc intake and biological ageing and to evaluate the modifying effect of physical exercise.

Methods

Data were extracted from 68,947 participants in the Biobank. Daily zinc intake and biological age were calculated using standard equations, and physical exercise was measured by the metabolic equivalent of task (MET) per week. Generalized linear regression models, adjusted for confounding factors, were employed to explore the associations between zinc intake and biological ageing. Pre-specified subgroup and sensitivity analyses were performed to identify effect modification of MET and to validate the robustness of findings, respectively.

Results

The regression models revealed that zinc intake with recommended dose was associated with 0.13-year delayed biological age [95 % Confidence Interval (CI) = −0.21 to −0.05], while an excessive intake of zinc (>40 mg per day) was associated with 3.23-year biological age acceleration (95 % CI = 0.18 to 6.28). Participants adhering to the recommended zinc intake combined with sufficient physical exercise (>600 MET per week) demonstrated a 31 % lower likelihood of experiencing accelerated biological ageing compared to those with inadequate zinc intake and insufficient physical exercise (Odds Ratio = 0.69, 95 % CI = 0.66 to 0.74, p < 0.001). Subgroup analyses indicated that the association between zinc intake and delayed biological ageing was more pronounced in the low-income population with an annual household income before tax of less than £30,999 (P-interaction <0.001). Sensitivity analyses confirmed the robustness of these results.

Conclusion

A recommended dose of zinc intake is associated with delayed biological ageing, with physical exercise exceeding 600 MET per week enhancing this association. Conversely, excessive zinc intake is linked to accelerated biological ageing. We suggest that people take daily zinc supplements with caution.

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来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.