生物3D打印技术在牙周组织再生中的应用进展

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-04-25 DOI:10.1016/j.isci.2025.112532

Huanhuan Chen , Yu Wang , Yue Lai , Chenda Meng , Xiner Ning , Tianmin Xu , Guangying Song , Yunfan Zhang , Yifan Lin , Bing Han

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引用次数: 0

摘要

用于牙周组织再生的3D生物打印技术是一种先进的制造技术，它利用三维（3D）打印原理来制造复杂的、可行的结构，专门设计用于满足牙周再生的需求。通过3D生物打印的个性化组织替代品具有促进组织缺陷区域组织再生的能力。然而，目前用于牙周组织工程的生物3D打印仍然面临着许多巨大的挑战，包括选择最佳的流变学特性以进行精确打印，确保生物相容性，以及促进细胞的一致结合。本文介绍了牙周炎的发病机制以及生物3D打印技术的原理和分类。本文综述了生物3D打印尖端生物制造技术在牙周整体再生中的应用进展，旨在为生物3D打印技术的优化和未来临床应用的潜在方向提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances of 3D bioprinting technology for periodontal tissue regeneration

3D bioprinting technology for periodontal tissue regeneration is an advanced manufacturing technique that utilizes three-dimensional (3D) printing principles to fabricate intricate, viable structures that are specifically devised to meet with the demand for the periodontal regeneration. Personalized tissue substitutes through 3D bioprinting possesses the capability to promote tissue regeneration in tissue-defective regions. However, the current 3D bioprinting for periodontal tissue engineering still is confronted with many huge challenges that include selecting the optimal rheological properties for precise printing, ensuring the biocompatibility, and facilitating the consistent cell incorporation. In this review, we introduced the pathogenesis of periodontitis and the principle and categories of 3D bioprinting technology. We provided a comprehensive overview of the latest advancements in the application of cutting-edge biofabrication technology of 3D bioprinting for the overall periodontal regeneration, aiming to provide valuable insights for the optimization of 3D bioprinting technology and potential directions for future clinical application.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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