Winford Janvrin , Jacob Martin , Daniel Hancock , Angelo Varillas , Austin R.J. Downey , Perry J. Pellechia , Joud Satme , Sang Hee Won
{"title":"开源紧凑的时域氢(1H)核磁共振系统用于现场部署","authors":"Winford Janvrin , Jacob Martin , Daniel Hancock , Angelo Varillas , Austin R.J. Downey , Perry J. Pellechia , Joud Satme , Sang Hee Won","doi":"10.1016/j.ohx.2025.e00651","DOIUrl":null,"url":null,"abstract":"<div><div>This paper presents a compact, low-cost time-domain nuclear magnetic resonance (TD-NMR) system based on a 0.5 T permanent magnet designed for in-situ <span><math><msup><mrow></mrow><mrow><mn>1</mn></mrow></msup></math></span>H measurements. Unlike conventional high-field nuclear magnetic resonance (NMR) spectrometers, this system emphasizes relaxation times rather than chemical shifts, enabling material property analysis without large magnets or complex spectral processing. The hardware employs an off-the-shelf data acquisition and control system along with a custom PCB for signal conditioning, ensuring straightforward deployment and reduced costs. The system’s core sequence is a Carr-Purcell-Meiboom-Gill pulse train, chosen for efficient <span><math><msub><mrow><mi>T</mi></mrow><mrow><mn>2</mn></mrow></msub></math></span> relaxation measurements under varying magnetic susceptibilities. By focusing on relaxation measurements, this approach bypasses complexities of high-resolution spectroscopy, enhances signal-to-noise in low-field conditions, and enables robust characterization across challenging environmental settings. We validate the system using aqueous Copper(II) sulfate solutions, correlating T<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span> values with copper concentrations to simulate environmental heavy metal contamination monitoring. Prior work has demonstrated versatility in fuel property analysis and environmental sensing, confirming broad applicability for this portable platform. While packaging and integration with ancillary equipment (e.g., flow-through systems) are not covered, the platform serves as a versatile foundation for specialized deployments. Its open-source design and affordability aim to democratize NMR technology and extending its utility beyond conventional laboratory environments. This accessible configuration fosters widespread educational and professional use.</div></div>","PeriodicalId":37503,"journal":{"name":"HardwareX","volume":"22 ","pages":"Article e00651"},"PeriodicalIF":2.0000,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Open-source compact time-domain hydrogen (1H) NMR System for Field Deployment\",\"authors\":\"Winford Janvrin , Jacob Martin , Daniel Hancock , Angelo Varillas , Austin R.J. Downey , Perry J. Pellechia , Joud Satme , Sang Hee Won\",\"doi\":\"10.1016/j.ohx.2025.e00651\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>This paper presents a compact, low-cost time-domain nuclear magnetic resonance (TD-NMR) system based on a 0.5 T permanent magnet designed for in-situ <span><math><msup><mrow></mrow><mrow><mn>1</mn></mrow></msup></math></span>H measurements. Unlike conventional high-field nuclear magnetic resonance (NMR) spectrometers, this system emphasizes relaxation times rather than chemical shifts, enabling material property analysis without large magnets or complex spectral processing. The hardware employs an off-the-shelf data acquisition and control system along with a custom PCB for signal conditioning, ensuring straightforward deployment and reduced costs. The system’s core sequence is a Carr-Purcell-Meiboom-Gill pulse train, chosen for efficient <span><math><msub><mrow><mi>T</mi></mrow><mrow><mn>2</mn></mrow></msub></math></span> relaxation measurements under varying magnetic susceptibilities. By focusing on relaxation measurements, this approach bypasses complexities of high-resolution spectroscopy, enhances signal-to-noise in low-field conditions, and enables robust characterization across challenging environmental settings. We validate the system using aqueous Copper(II) sulfate solutions, correlating T<span><math><msub><mrow></mrow><mrow><mn>2</mn></mrow></msub></math></span> values with copper concentrations to simulate environmental heavy metal contamination monitoring. Prior work has demonstrated versatility in fuel property analysis and environmental sensing, confirming broad applicability for this portable platform. While packaging and integration with ancillary equipment (e.g., flow-through systems) are not covered, the platform serves as a versatile foundation for specialized deployments. Its open-source design and affordability aim to democratize NMR technology and extending its utility beyond conventional laboratory environments. 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Open-source compact time-domain hydrogen (1H) NMR System for Field Deployment
This paper presents a compact, low-cost time-domain nuclear magnetic resonance (TD-NMR) system based on a 0.5 T permanent magnet designed for in-situ H measurements. Unlike conventional high-field nuclear magnetic resonance (NMR) spectrometers, this system emphasizes relaxation times rather than chemical shifts, enabling material property analysis without large magnets or complex spectral processing. The hardware employs an off-the-shelf data acquisition and control system along with a custom PCB for signal conditioning, ensuring straightforward deployment and reduced costs. The system’s core sequence is a Carr-Purcell-Meiboom-Gill pulse train, chosen for efficient relaxation measurements under varying magnetic susceptibilities. By focusing on relaxation measurements, this approach bypasses complexities of high-resolution spectroscopy, enhances signal-to-noise in low-field conditions, and enables robust characterization across challenging environmental settings. We validate the system using aqueous Copper(II) sulfate solutions, correlating T values with copper concentrations to simulate environmental heavy metal contamination monitoring. Prior work has demonstrated versatility in fuel property analysis and environmental sensing, confirming broad applicability for this portable platform. While packaging and integration with ancillary equipment (e.g., flow-through systems) are not covered, the platform serves as a versatile foundation for specialized deployments. Its open-source design and affordability aim to democratize NMR technology and extending its utility beyond conventional laboratory environments. This accessible configuration fosters widespread educational and professional use.
HardwareXEngineering-Industrial and Manufacturing Engineering
CiteScore
4.10
自引率
18.20%
发文量
124
审稿时长
24 weeks
期刊介绍:
HardwareX is an open access journal established to promote free and open source designing, building and customizing of scientific infrastructure (hardware). HardwareX aims to recognize researchers for the time and effort in developing scientific infrastructure while providing end-users with sufficient information to replicate and validate the advances presented. HardwareX is open to input from all scientific, technological and medical disciplines. Scientific infrastructure will be interpreted in the broadest sense. Including hardware modifications to existing infrastructure, sensors and tools that perform measurements and other functions outside of the traditional lab setting (such as wearables, air/water quality sensors, and low cost alternatives to existing tools), and the creation of wholly new tools for either standard or novel laboratory tasks. Authors are encouraged to submit hardware developments that address all aspects of science, not only the final measurement, for example, enhancements in sample preparation and handling, user safety, and quality control. The use of distributed digital manufacturing strategies (e.g. 3-D printing) is encouraged. All designs must be submitted under an open hardware license.