外泌体在心血管疾病中的作用：心肌细胞细胞间通讯的关键调节因子

IF 3.7 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-05-05 DOI:10.1021/acsomega.4c1142310.1021/acsomega.4c11423

Liuxin Li, Zhidong Zheng, Wenyu Lan, Nan Tang, Deju Zhang, Jitao Ling, Yuting Wu, Pingping Yang, Linhua Fu, Jianping Liu, Jing Zhang, Peng Yu* and Tieqiu Huang*,

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引用次数: 0

摘要

在心血管系统中，不同类型的心血管细胞可分泌特异性外泌体，参与心血管功能的维持和疾病的发生发展。外泌体携带生物活性物质，如来自细胞来源的蛋白质和核酸，可作为疾病诊断和预后评估的生物标志物。此外，外泌体介导的细胞间通讯在心血管疾病的发生和发展中起着关键作用，已成为潜在的治疗靶点。本文强调了解外泌体在心血管疾病中的作用机制的重要性，并系统详细介绍了目前对外泌体作为心肌细胞细胞间通讯调节因子的认识，为今后的研究和治疗干预提供基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Role of Exosomes in Cardiovascular Disease: A Key Regulator of Intercellular Communication in Cardiomyocytes

In the cardiovascular system, different types of cardiovascular cells can secrete specific exosomes and participate in the maintenance of cardiovascular function and the occurrence and development of diseases. Exosomes carry biologically active substances such as proteins and nucleic acids from cells of origin and can be used as biomarkers for disease diagnosis and prognosis assessment. In addition, exosome-mediated intercellular communication plays a key role in the occurrence and development of cardiovascular diseases and has become a potential therapeutic target. This article emphasizes the importance of understanding the mechanism of exosomes in cardiovascular diseases and systematically details the current understanding of exosomes as regulators of intercellular communication in cardiomyocytes, providing a basis for future research and therapeutic intervention.

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.