Yanhua Chen, Yiran He, Min Jiang, Ye Shen, Xuewen Zheng, Ying Shi, Jingyi Qin, Yayun Gu, Xin Li, Zhaoxu Luo, Shengquan Liu, Xiaochuan Ma*, Jiong Li* and Kefeng Pu*,
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Enhancing Immune Responses and Tumor Inhibition with Iron Oxide Nanoparticle Adjuvants
Adjuvants are essential for enhancing vaccine-induced immune responses, yet the number of approved adjuvants remains limited, which necessitates the development of safe, and effective options. This study identifies iron oxide nanoparticles (IONPs) as potent activators of the NF-κB and IRF signaling pathways, suggesting their potential as adjuvants. IONPs were found to promote dendritic cell maturation and activation, enhance IgG expression, and stimulate robust Th1/Th2 immune responses in mice. Furthermore, IONPs induced the proliferation of CD8+ T cells and germinal center B cells, contributing to a durable humoral immune response. Importantly, IONPs demonstrated efficacy in preventing and treating B16F10 tumors in mice. These findings position IONPs as promising candidates for future adjuvant development.
期刊介绍：
The journal Chemistry of Materials focuses on publishing original research at the intersection of materials science and chemistry. The studies published in the journal involve chemistry as a prominent component and explore topics such as the design, synthesis, characterization, processing, understanding, and application of functional or potentially functional materials. The journal covers various areas of interest, including inorganic and organic solid-state chemistry, nanomaterials, biomaterials, thin films and polymers, and composite/hybrid materials. The journal particularly seeks papers that highlight the creation or development of innovative materials with novel optical, electrical, magnetic, catalytic, or mechanical properties. It is essential that manuscripts on these topics have a primary focus on the chemistry of materials and represent a significant advancement compared to prior research. Before external reviews are sought, submitted manuscripts undergo a review process by a minimum of two editors to ensure their appropriateness for the journal and the presence of sufficient evidence of a significant advance that will be of broad interest to the materials chemistry community.
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