具有哌嗪和苯氧丙醇官能团的1,3,4-恶二唑衍生物的合成

IF 3.7 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-05-03 DOI:10.1021/acsomega.5c0129010.1021/acsomega.5c01290

Deepak Kumar, Suryakanta Dalai, Girish Chandra Sharma and Mukesh Jangir*,

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引用次数: 0

摘要

1-氨基-3-（3-（5-（4-苯基哌嗪-1-基）甲基）-1,3,4-恶二唑-3-基）苯氧基)丙烷-2-醇杂环衍生物的合成重点研究了1,3,4-恶二唑的特定哌嗪和哌啶衍生物。这些化合物是生物学研究的重要基序。建立了一种以1,3,4，-恶二唑为底物的哌嗪和哌啶衍生物的有效方法。该途径产率高，反应干净，适用底物范围广。这一途径提供了新的生物学上有用的部分，可以进一步研究其适用性。

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Synthesis of a Novel 1,3,4-Oxadiazole Derivative with Piperazine and Phenoxypropanol Functionalities

Synthesis of novel heterocyclic derivatives of 1-amino-3-(3-(5-((4-phenylpiperazin-1-yl)methyl)-1,3,4-oxadiazol-3-yl)phenoxy)propan-2-ol is focused on specific piperazine and piperidine derivatives of 1,3,4-oxadiazole. These compounds are a distinguished motif for biological studies. An effective piperazine and piperidine derivatives methodology on 1,3,4,-oxadiazole substrates has been developed. This pathway along with good yields and clean reactions has a broad substrate scope. This pathway provides new biologically useful moieties that can further be investigated for their applicability.

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.