改进肿瘤同源靶向催化治疗的单原子催化动力学。

IF 36.3 1区材料科学 Q1 Engineering

Nano-Micro Letters Pub Date : 2025-05-12 DOI:10.1007/s40820-025-01735-y

Hengke Liu, Shan Lei, Hongyu Li, Jiayingzi Wu, Ting He, Jing Lin, Peng Huang

{"title":"改进肿瘤同源靶向催化治疗的单原子催化动力学。","authors":"Hengke Liu, Shan Lei, Hongyu Li, Jiayingzi Wu, Ting He, Jing Lin, Peng Huang","doi":"10.1007/s40820-025-01735-y","DOIUrl":null,"url":null,"abstract":"<div><h2> Highlights</h2><div>\n \n <ul>\n <li>\n <p>Developed a dual-enzyme cascade system integrating iridium single-atom nanozymes with glucose oxidase, optimizing hydrogen peroxide production, acidity, and temperature within the tumor microenvironment to markedly improve catalytic therapy efficacy.</p>\n </li>\n <li>\n <p>Functionalized the cascade reaction system with cancer cell membranes to achieve homologous targeting and high biocompatibility, ensuring accurate accumulation at tumor sites while minimizing off-target effects.</p>\n </li>\n </ul>\n </div></div>","PeriodicalId":714,"journal":{"name":"Nano-Micro Letters","volume":"17 1","pages":""},"PeriodicalIF":36.3000,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40820-025-01735-y.pdf","citationCount":"0","resultStr":"{\"title\":\"Refining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic Therapy\",\"authors\":\"Hengke Liu, Shan Lei, Hongyu Li, Jiayingzi Wu, Ting He, Jing Lin, Peng Huang\",\"doi\":\"10.1007/s40820-025-01735-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h2> Highlights</h2><div>\\n \\n <ul>\\n <li>\\n <p>Developed a dual-enzyme cascade system integrating iridium single-atom nanozymes with glucose oxidase, optimizing hydrogen peroxide production, acidity, and temperature within the tumor microenvironment to markedly improve catalytic therapy efficacy.</p>\\n </li>\\n <li>\\n <p>Functionalized the cascade reaction system with cancer cell membranes to achieve homologous targeting and high biocompatibility, ensuring accurate accumulation at tumor sites while minimizing off-target effects.</p>\\n </li>\\n </ul>\\n </div></div>\",\"PeriodicalId\":714,\"journal\":{\"name\":\"Nano-Micro Letters\",\"volume\":\"17 1\",\"pages\":\"\"},\"PeriodicalIF\":36.3000,\"publicationDate\":\"2025-05-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s40820-025-01735-y.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano-Micro Letters\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40820-025-01735-y\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Micro Letters","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s40820-025-01735-y","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Engineering","Score":null,"Total":0}

引用次数: 0

摘要

单原子纳米酶（SAzymes）在肿瘤催化治疗方面具有巨大的潜力，但由于肿瘤微环境中催化效率低，其效果往往受到影响。该效率主要受过氧化氢（H2O2）可用性、酸度和温度等关键因素的影响。同时优化这些关键因素对肿瘤催化治疗提出了重大挑战。在这项研究中，我们开发了一个综合的策略来完善单原子催化动力学，通过双酶驱动的级联反应来增强肿瘤的催化治疗。利用具有高催化活性的铱（Ir）酶和天然酶葡萄糖氧化酶（GOx）构建了级联反应体系。由于其表面积大，GOx被Ir SAzymes装载。然后，利用癌细胞膜对双酶驱动级联反应体系进行修饰，提高生物相容性，实现肿瘤同源靶向能力。GOx催化反应可以产生丰富的H2O2，降低局部pH，从而优化关键的反应限制因素。此外，在激光照射下，Ir SAzymes可以提高局部温度，进一步提高双酶体系的催化效率。这种全面的优化使Ir SAzymes的性能最大化，显著提高了催化治疗的效率。我们的发现提出了一种改进肿瘤同源靶向催化治疗的单原子催化动力学的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Refining Single-Atom Catalytic Kinetics for Tumor Homologous-Targeted Catalytic Therapy

Highlights

Developed a dual-enzyme cascade system integrating iridium single-atom nanozymes with glucose oxidase, optimizing hydrogen peroxide production, acidity, and temperature within the tumor microenvironment to markedly improve catalytic therapy efficacy.
Functionalized the cascade reaction system with cancer cell membranes to achieve homologous targeting and high biocompatibility, ensuring accurate accumulation at tumor sites while minimizing off-target effects.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nano-Micro Letters NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

CiteScore

32.60

自引率

4.90%

发文量

981

审稿时长

1.1 months

期刊介绍： Nano-Micro Letters is a peer-reviewed, international, interdisciplinary, and open-access journal published under the SpringerOpen brand. Nano-Micro Letters focuses on the science, experiments, engineering, technologies, and applications of nano- or microscale structures and systems in various fields such as physics, chemistry, biology, material science, and pharmacy.It also explores the expanding interfaces between these fields. Nano-Micro Letters particularly emphasizes the bottom-up approach in the length scale from nano to micro. This approach is crucial for achieving industrial applications in nanotechnology, as it involves the assembly, modification, and control of nanostructures on a microscale.