（-）-钠素E的全合成及结构修正。

IF 16.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Angewandte Chemie International Edition Pub Date : 2025-05-12 DOI:10.1002/anie.202506247

Philipp Schoch,Tanja Gaich

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引用次数: 0

摘要

我们报道了马拉巴里烷三萜钠皂素E的全合成，这是迄今为止首次合成马拉巴里烷天然产物。两个关键片段的对映选择性合成，随后通过Mukaiyama醛醇反应偶联，在会聚合成中提供了三萜框架。对合成材料的彻底分析导致了先前未分配的立体中心（C17）的阐明以及C27的构型的重新分配。这使得在中心乳酸菌部分的相对构型的结构修正成为可能。

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Total Synthesis and Structural Revision of (-)-Sodagnitin E.

We report the total synthesis of malabaricane triterpene sodagnitin E, marking the first synthesis of any malabaricane natural product to date. The enantioselective synthesis of two key fragments, followed by their coupling via a Mukaiyama aldol reaction delivered the triterpene framework in a convergent synthesis. A thorough analysis of the synthetic material led to the elucidation of a previously unassigned stereocenter (C17) as well as the reassignment of the configuration at C27. This enabled the structural revision of the relative configuration at the central lactol moiety.

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来源期刊

Angewandte Chemie International Edition 化学-化学综合

CiteScore

26.60

自引率

6.60%

发文量

3549

审稿时长

1.5 months

期刊介绍： Angewandte Chemie, a journal of the German Chemical Society (GDCh), maintains a leading position among scholarly journals in general chemistry with an impressive Impact Factor of 16.6 (2022 Journal Citation Reports, Clarivate, 2023). Published weekly in a reader-friendly format, it features new articles almost every day. Established in 1887, Angewandte Chemie is a prominent chemistry journal, offering a dynamic blend of Review-type articles, Highlights, Communications, and Research Articles on a weekly basis, making it unique in the field.