{"title":"不依赖氧的硫酸盐自由基和Fe2+修饰种植体用于感染性骨缺损的快速灭菌和骨整合。","authors":"Ziyou Wang,Yiling Huang,Shuai He,Meng Li,Jing Gong,Lei Cheng,Jiyao Li,Yi Deng,Kunneng Liang","doi":"10.1021/acsnano.5c04147","DOIUrl":null,"url":null,"abstract":"Currently, emerging dynamic therapy has gradually become a frequently used strategy for treating infectious bone defects via a rise in reactive oxygen species (ROS) levels, which can bring about oxidative harm to bacteria. However, ROS can be generated only under conditions of exogenous energy, limited by energy penetration or dependence on the existence of internal O2/H2O2. Thus, we designed Na2S2O8-decorated polyetheretherketone implants activated by Fe2+ for infected bone defects. In vitro experiments show that they generate sulfate radical (·SO4-) and hydroxyl radical (·OH) without O2/H2O2 existence, effectively killing bacteria. Additionally, the released Fe2+ enters bacteria and triggers ferroptosis-like death via lipid peroxidation. In vivo experiments show implants achieve an ideal effect of bone integration through a high-efficiency bactericidal effect and enhanced osteogenic activity. As envisioned, our proposed strategy offers a promising approach to halt refractory infection of bone tissue by autonomously catalyzing ROS storms and ferroptosis-like death, facilitating bone-defect recovery.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"57 1","pages":""},"PeriodicalIF":15.8000,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oxygen-Independent Sulfate Radical and Fe2+-Modified Implants for Fast Sterilization and Osseointegration of Infectious Bone Defects.\",\"authors\":\"Ziyou Wang,Yiling Huang,Shuai He,Meng Li,Jing Gong,Lei Cheng,Jiyao Li,Yi Deng,Kunneng Liang\",\"doi\":\"10.1021/acsnano.5c04147\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Currently, emerging dynamic therapy has gradually become a frequently used strategy for treating infectious bone defects via a rise in reactive oxygen species (ROS) levels, which can bring about oxidative harm to bacteria. However, ROS can be generated only under conditions of exogenous energy, limited by energy penetration or dependence on the existence of internal O2/H2O2. Thus, we designed Na2S2O8-decorated polyetheretherketone implants activated by Fe2+ for infected bone defects. In vitro experiments show that they generate sulfate radical (·SO4-) and hydroxyl radical (·OH) without O2/H2O2 existence, effectively killing bacteria. Additionally, the released Fe2+ enters bacteria and triggers ferroptosis-like death via lipid peroxidation. In vivo experiments show implants achieve an ideal effect of bone integration through a high-efficiency bactericidal effect and enhanced osteogenic activity. As envisioned, our proposed strategy offers a promising approach to halt refractory infection of bone tissue by autonomously catalyzing ROS storms and ferroptosis-like death, facilitating bone-defect recovery.\",\"PeriodicalId\":21,\"journal\":{\"name\":\"ACS Nano\",\"volume\":\"57 1\",\"pages\":\"\"},\"PeriodicalIF\":15.8000,\"publicationDate\":\"2025-05-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Nano\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1021/acsnano.5c04147\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Nano","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1021/acsnano.5c04147","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Oxygen-Independent Sulfate Radical and Fe2+-Modified Implants for Fast Sterilization and Osseointegration of Infectious Bone Defects.
Currently, emerging dynamic therapy has gradually become a frequently used strategy for treating infectious bone defects via a rise in reactive oxygen species (ROS) levels, which can bring about oxidative harm to bacteria. However, ROS can be generated only under conditions of exogenous energy, limited by energy penetration or dependence on the existence of internal O2/H2O2. Thus, we designed Na2S2O8-decorated polyetheretherketone implants activated by Fe2+ for infected bone defects. In vitro experiments show that they generate sulfate radical (·SO4-) and hydroxyl radical (·OH) without O2/H2O2 existence, effectively killing bacteria. Additionally, the released Fe2+ enters bacteria and triggers ferroptosis-like death via lipid peroxidation. In vivo experiments show implants achieve an ideal effect of bone integration through a high-efficiency bactericidal effect and enhanced osteogenic activity. As envisioned, our proposed strategy offers a promising approach to halt refractory infection of bone tissue by autonomously catalyzing ROS storms and ferroptosis-like death, facilitating bone-defect recovery.
期刊介绍:
ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.