SARS-CoV-2损害心肌细胞线粒体，并与covid - 19相关的长期心血管症状有关

IF 11.4 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2025-05-10 DOI:10.1016/j.jare.2025.05.013

Wenliang Che, Shuai Guo, Yanqun Wang, Xiaohua Wan, Bingyu Tan, Hailing Li, Jiasuer Alifu, Mengyun Zhu, Zesong Chen, Peiyao Li, Lei Zhang, Zhaoyong Zhang, Yiliang Wang, Xiaohan Huang, Xinsheng Wang, Jian Zhu, Xijiang Pan, Fa Zhang, Peiyi Wang, Sen-Fang Sui, Zheng Liu

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引用次数: 0

摘要

随着COVID-19大流行成为地方性疾病，对与COVID-19相关的心血管问题保持警惕仍然至关重要，尽管其具体的病理生理机制在很大程度上尚未得到探索。我们的研究调查了在感染SARS-CoV-2后很长一段时间内观察到的持续心血管症状，这种情况通常被称为“长COVID”，已严重影响了全球数百万人。方法：我们仔细描述了5例患者的心血管结局，包括一系列严重的情况，如运动期间心源性猝死、冠状动脉粥样硬化性心脏病、急性下壁心肌梗死和急性心肌炎。结果5例患者均诊断为心肌炎，经心内膜活检及组织化学染色证实，均有心肌组织炎症细胞浸润。至关重要的是，电子显微镜显示这些患者的心肌细胞中存在广泛的线粒体空泡和肌丝降解。这些发现在sars - cov -2感染的小鼠中得到了反映，这表明与长COVID相关的心脏效应可能存在潜在的细胞机制。结论我们的研究结果证明了SARS-CoV-2对线粒体完整性的深远影响，揭示了Long COVID对心血管的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations

查看原文本刊更多论文

SARS-CoV-2 damages cardiomyocyte mitochondria and implicates long COVID-associated cardiovascular manifestations

Introduction

With the COVID-19 pandemic becoming endemic, vigilance for Long COVID-related cardiovascular issues remains essential, though their specific pathophysiology is largely unexplored.

Objectives

Our study investigates the persistent cardiovascular symptoms observed in individuals long after contracting SARS-CoV-2, a condition commonly referred to as “Long COVID”, which has significantly affected millions globally.

Methods

We meticulously describe the cardiovascular outcomes in five patients, encompassing a range of severe conditions such as sudden cardiac death during exercise, coronary atherosclerotic heart disease, acute inferior myocardial infarction, and acute myocarditis.

Results

All five patients were diagnosed with myocarditis, confirmed through endomyocardial biopsy and histochemical staining, which identified inflammatory cell infiltration in their heart tissue. Crucially, electron microscopy revealed widespread mitochondrial vacuolations and the presence of myofilament degradation within the cardiomyocytes of these patients. These findings were mirrored in SARS-CoV-2-infected mice, suggesting a potential underlying cellular mechanism for the cardiac effects associated with Long COVID.

Conclusion

Our findings demonstrate a profound impact of SARS-CoV-2 on mitochondrial integrity, shedding light on the cardiovascular implications of Long COVID.

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.