麝香椰子水醇提取物对啮齿类动物具有利尿作用

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-05-06 DOI:10.1016/j.fitote.2025.106589

Jhônata Costa Moura , Thâmara de Paula Reis Sousa Pires , Ellen Caroline da Silva Penha , Vinicius Santos Mendes , Beatriz da Silva Ferreira de Lima , Lara Possapp Andrade , Gabriel Antônio Bezerra Costa e Souza , Nicolas Melo de Cerqueira Salgado , Mateus Balbino Barbosa De Carvalho , Emanoel Ribeiro De Brito Junior , Caritas De Jesus Silva Mendonça , Cláudia Quintino da Rocha , Rachel Melo Ribeiro

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引用次数: 0

摘要

最近的研究表明，椰子作为一种治疗心血管疾病的工具具有巨大的生物技术潜力。目的评价黄花杏仁提取物（SYA）对正常血压Wistar大鼠的利尿作用。方法采用蒸馏水（10 mL/Kg，口服）饲养，分别置于代谢笼中。将实验动物随机分为4组：健康对照组（1组）给予蒸馏水（0.01 g/Kg），对照组（2组）给予标准药物（速尿0.01 g/Kg），对照组（3组）和对照组（4组）给予SYA单次灌胃，连续7 d。SYA的剂量分别为0.1 g/Kg和0.3 g/Kg。测定血清和尿液生化指标。测定尿电解质，测定尿钠活性（NA）、唾液活性（AS）和碳酸酐酶抑制活性（CAI）。结果植物化学研究表明，SYA含有丰富的酚类化合物和黄酮类化合物，具有较高的抗氧化活性。在血清生化指标方面，SYA 0.3 g/Kg组血糖仅轻微升高（113.4±6.55 mg/dL）。在电解质排泄方面，与速尿0.01 g/Kg组相比，0.3 g/Kg SYA组大鼠的K+排泄量增加（p = 0.04），与对照组、速尿和0.1 g/Kg SYA组相比，Cl -排泄量增加(p <；0.05)。所有试验剂量的SYA产生的CAI指数<；0.8。处理没有引起体重增加、水和饲料消耗、密度和尿ph的显著变化。在处理的第6天，与对照组相比，使用提取物的两组表现出更大的利尿活性(p <；0.05)。第7天，观察剂量依赖性利尿活性。结论这些研究结果支持了cocoides作为一种有前景的天然利尿剂的潜力，值得进一步研究其作用机制和治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Hydroalcoholic extract from Syagrus cocoides Martius almonds (ariri coconut) induces diuretic effects in rodents

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Hydroalcoholic extract from Syagrus cocoides Martius almonds (ariri coconut) induces diuretic effects in rodents

Background

Recent studies point to the great biotechnological potential of Syagrus cocoides as a tool for treating cardiovascular disorders.

Purpose

Evaluate the diuretic activity of the extract of S. cocoides Martius almonds (SYA) in normotensive Wistar rats.

Methods

The animals received distilled water (10 mL/Kg, orally) and were placed individually in metabolic cages. The animals were randomized into 4 groups: Group I, the health control, received distilled water (0.01 g/Kg), Group II, treated with the standard drug (Furosemide 0.01 g/Kg) and Group III and IV, treated with SYA by gavage over 7 consecutive days, in a single daily dose. The doses of SYA were 0.1 g/Kg and 0.3 g/Kg, respectively. Serum and urine biochemical parameters were assessed. Urinary electrolytes were measured, and Natriuretic Activity (NA), Saliuretic Activity (AS), and Carbonic Anhydrase Inhibitory Activity (CAI) were determined.

Results

The phytochemical study of SYA showed it to be rich in phenols and flavonoids, with high antioxidant activity. Regarding serum biochemical parameters, only a slight increase in glycemia was observed in the SYA 0.3 g/Kg group (113.4 ± 6.55 mg/dL). About electrolyte excretion, SYA in rats treated with 0.3 g/Kg produced greater K⁺ excretion when compared to the group treated with Furosemide 0.01 g/Kg (p = 0.04) and showed an increase in Cl⁻ excretion compared to the Control group, Furosemide and SYA-0.1 g/Kg (p < 0.05). All test doses of SYA produced a CAI index <0.8. The treatment did not cause significant changes in weight gain, water and feed consumption, density, and urinary pH. On the 6th day of treatment, the two groups treated with the extract showed greater diuretic activity when compared to the Control group (p < 0.05). On the 7th day, dose-dependent diuretic activity was observed.

Conclusion

These findings support the potential of S. cocoides as a promising natural agent for diuretic therapy and warrant further investigation into its mechanisms of action and therapeutic applications.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.