SOCS家族在免疫调节和自身免疫发病机制中的作用的新认识

IF 11.4 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2025-05-10 DOI:10.1016/j.jare.2025.05.020

Shiyi Liu, Mingwei Wang, Liangjie Xu, Daihua Deng, Liwei Lu, Jie Tian, Dongmei Zhou, Ke Rui

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引用次数: 0

摘要

细胞因子信号传导抑制因子（SOCS）蛋白通过与细胞因子受体和信号蛋白相互作用以及靶向相关蛋白降解来调节信号转导。最近的研究表明，SOCS蛋白作为细胞因子信号网络的关键抑制剂，在先天和适应性免疫反应中发挥关键作用。在这篇综述中，我们旨在讨论近年来在了解SOCS蛋白在各种免疫细胞中的复杂功能以及SOCS蛋白在人类健康和疾病中的作用方面的进展。越来越多的证据表明，在自身免疫性疾病的发生过程中，SOCS蛋白经常出现失调，这表明靶向SOCS蛋白的治疗可能会带来临床益处。本文综述了SOCS蛋白在免疫调节和自身免疫发病机制中的全面认识，并强调了SOCS相关的模拟肽在免疫治疗中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

New insight into the role of SOCS family in immune regulation and autoimmune pathogenesis

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New insight into the role of SOCS family in immune regulation and autoimmune pathogenesis

Background

Suppressor of cytokine signaling (SOCS) proteins regulate signal transduction by interacting with cytokine receptors and signaling proteins and targeting associated proteins for degradation. Recent studies have demonstrated that the SOCS proteins serve as crucial inhibitors in cytokine signaling networks and play a pivotal role in both innate and adaptive immune responses.

Aim of Review

In this review, we aim to discuss recent advancements in understanding the complex functions of SOCS proteins in various immune cells, as well as the effects of SOCS proteins in human health and diseases. Increasing evidence indicates that SOCS proteins are frequently dysregulated in developing autoimmune diseases, suggesting that therapeutic targeting of SOCS proteins could provide clinical benefit.

Key Scientific Concepts of Review

This review provides a comprehensive understanding of SOCS proteins in immune regulation and autoimmune pathogenesis, it also highlights the role of SOCS-related mimetic peptides in immunotherapy.

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.