铁催化的顺序硅氢化反应

IF 14.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2025-05-09 DOI:10.1038/s41467-025-59364-3

Xue Wang, Jiajin Zhao, Dongyang Wang, Liang Deng, Zhan Lu

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引用次数: 0

摘要

高区域，非映对和对映选择性铁催化的邻烷基-正炔-苯基硅烷与炔的顺序硅氢化反应报道了各种5-，6-和7元苯硅环在60-94%的收率高达95:5 rr， 95:5 dr和99% ee。手性全碳取代硅立体苯并硅环也可以通过三次硅氢化反应得到。在调节硅氢化反应的区域选择性和对映选择性时，观察到配体独特的电子效应。通过变时间归一化分析（VTNA）和H/D交换实验，提出了一种可能的机理。

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Iron-catalyzed sequential hydrosilylation

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Iron-catalyzed sequential hydrosilylation

Highly regio-, diastereo- and enantioselective iron-catalyzed sequential hydrosilylation of o-alk-n-enyl-phenyl silanes with alkynes is reported for various 5-, 6-, and 7-membered benzosilacycles in 60-94% yields with up to 95:5 rr, 95:5 dr, and 99% ee. Chiral fully carbon-substituted silicon-stereogenic benzosilacycles could also be obtained via triple hydrosilylation reactions. The unique electronic effect of ligands is observed while adjusting the regioselectivity and enantioselectivity in hydrosilylation reactions. A possible mechanism has been proposed by variable time normalization analysis (VTNA) and H/D exchange experiment.

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.