Taylor-Couette流提高手性分辨效率

IF 8.1 1区工程技术 Q1 ENGINEERING, CHEMICAL

Separation and Purification Technology Pub Date : 2025-05-08 DOI:10.1016/j.seppur.2025.133458

Dongbo Wang, Shilei Zhou, Yifu Chen, Mingyang Wang, Bowen Zhang, Dandan Han, Jingtao Wang, Junbo Gong

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引用次数: 0

摘要

由于对映体的物理和化学性质非常相似，实现对映体的纯化仍然具有挑战性。结晶分解是获得单个对映体最经济、最方便的方法之一。在这篇文章中，我们提出了一种强化的结晶分解方法，通过将聚合物添加剂与泰勒-库埃特流（TCF）结合使用，利用添加剂的超分子相互作用促进目标对映体的手性分解，并通过TCF加强手性对称性突破。TCF在结晶分解中的成功应用为从外消旋起始物质中方便、高效地纯化对映体提供了新的机会。

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Enhancing chiral resolution efficiency by Taylor-Couette flow

Achieving enantiomeric purification remains challenging due to the remarkably similar physical and chemical properties of enantiomers. Crystallization resolution is one of the most economical and convenient methods for obtaining single enantiomer. In this contribution, we present an intensified method for crystallization resolution by employing polymer additives in conjunction with Taylor-Couette Flow (TCF) which facilitates the chiral resolution of the target enantiomers by exploiting supramolecular interactions of the additive, and strengthening chiral symmetry breaking through TCF. The successful application of TCF in crystallization resolution offers new opportunities for facile and efficient purification of enantiomers from racemic starting materials.

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来源期刊

Separation and Purification Technology 工程技术-工程：化工

CiteScore

14.00

自引率

12.80%

发文量

2347

审稿时长

43 days

期刊介绍： Separation and Purification Technology is a premier journal committed to sharing innovative methods for separation and purification in chemical and environmental engineering, encompassing both homogeneous solutions and heterogeneous mixtures. Our scope includes the separation and/or purification of liquids, vapors, and gases, as well as carbon capture and separation techniques. However, it's important to note that methods solely intended for analytical purposes are not within the scope of the journal. Additionally, disciplines such as soil science, polymer science, and metallurgy fall outside the purview of Separation and Purification Technology. Join us in advancing the field of separation and purification methods for sustainable solutions in chemical and environmental engineering.