具有光热转化性能的再生丝素/纳米铯钨青铜复合膜的药物释放效果

IF 3.5 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Xinyi Wu, Huihui Li, Gang Deng, Yi Fang, Lin Ma, Guohua Wu
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引用次数: 0

摘要

本文将丝素蛋白与纳米铯钨青铜粒子(CsxWO3 NPs)共混,采用流铸法制备了不同质量分数的RSF/CsxWO3 NPs复合膜。3wt%-RSF/CsxWO3 NPs复合膜的力学性能最好,断裂伸长率和断裂强度分别为298.32±13.2%和8.11±0.47 MPa,分别比空白膜高170.3%和83.5%。FTIR和WAXD分析表明,CsxWO3 NPs降低了RSF膜的β-sheet和结晶度,这可能是RSF/CsxWO3 NPs复合膜力学性能改善的潜在原因。复合膜具有良好的光致加热性能,在氙灯(300 W, λ≥420 nm)下,1 min内温度由19.9℃达到79.0℃,10 min内温度达到94.0℃左右。将盐酸四环素(Th)装入复合膜后,发现CsxWO3 NPs/ RSF/Th复合膜对大肠杆菌和金黄色葡萄球菌具有良好的抑菌活性,且药物的缓释性能优于空白膜。该功能复合膜在医用伤口敷料和抗菌材料方面具有很大的应用潜力和发展前景。图形抽象
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Drug release effect of regenerated silk fibroin/nano cesium tungsten bronze composite film with photothermal conversion performance

In this paper, the silk fibroin was blended with nano-sized cesium tungsten bronze particles (CsxWO3 NPs), and the RSF/CsxWO3 NPs composite films with different mass fractions were prepared by flow-casting method. The mechanical properties of 3wt%-RSF/CsxWO3 NPs composite film are the best, the elongation at break and the strength at break are 298.32 ± 13.2% and 8.11 ± 0.47 MPa, respectively, which are 170.3% and 83.5% higher than that of blank film. FTIR and WAXD analysis show that CsxWO3 NPs reduces the β-sheet and crystallinity of RSF films, which may be the potential reason for the improvement of mechanical properties of RSF/CsxWO3 NPs composite films. The composite film has good photoinduced heating performance, in which the temperature reaches 79.0 °C from 19.9 °C within 1 min and about 94.0 °C within 10 min under xenon lamp (300 W, λ ≥ 420 nm). When tetracycline hydrochloride (Th) was loaded into the composite membrane, it was found that the CsxWO3 NPs/ RSF/Th composite membrane had good antibacterial activity against Escherichia coli and Staphylococcus aureus, and the sustained release performance of the drug was better than that of the blank membrane. This functional composite membrane has great application potential and development prospects in the medical wound dressing and antibacterial materials.

Graphical abstract

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来源期刊
Journal of Materials Science
Journal of Materials Science 工程技术-材料科学:综合
CiteScore
7.90
自引率
4.40%
发文量
1297
审稿时长
2.4 months
期刊介绍: The Journal of Materials Science publishes reviews, full-length papers, and short Communications recording original research results on, or techniques for studying the relationship between structure, properties, and uses of materials. The subjects are seen from international and interdisciplinary perspectives covering areas including metals, ceramics, glasses, polymers, electrical materials, composite materials, fibers, nanostructured materials, nanocomposites, and biological and biomedical materials. The Journal of Materials Science is now firmly established as the leading source of primary communication for scientists investigating the structure and properties of all engineering materials.
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