凤仙花叶提取物的毒理学特征和治疗潜力:探索抗菌、抗氧化、降糖和杀虫特性

Dharmalingam Kirubakaran , Venugopal Krishnan
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摘要

凤仙花(Impatiens chinensis)是一种传统药用植物,但其生物活性尚未得到充分的研究。本研究对其甲醇叶提取物的化学成分和生物学作用进行了深入研究,重点研究了其抗菌、抗氧化、降糖、分子对接、杀幼虫和杀虫等特性。提取物富含酚类和类黄酮,经GC-MS分析鉴定含有20种化合物。主要成分为十六酸(29.31 %)。FTIR分析揭示了功能基团的存在,如醇、烯烃和酰胺。该提取物具有较强的抗菌活性,特别是对金黄色葡萄球菌的抑制作用,并表现出明显的抗氧化作用,对DPPH和ABTS的抑制分别达到60.27 %和65.20 %。它还显示出相当大的抗糖尿病潜能,抑制α-淀粉酶(66.50 %)和α-葡萄糖苷酶(61.12 %)。与抗糖尿病蛋白(5NN8, 3W37)的分子对接研究显示了良好的相互作用,提示了潜在的糖尿病治疗应用。此外,该提取物还具有较强的杀幼虫和杀虫性能。综上所述,五倍子叶提取物具有丰富的生物活性,在医学研究中具有重要的应用价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Toxicological profile and therapeutic potentials of Impatiens chinensis leaf extract: Exploring antibacterial, antioxidant, antidiabetic and insecticidal properties
Impatiens chinensis, a plant known for its traditional medicinal applications, has not been thoroughly investigated for its biological activities. This research delves into the chemical composition and biological effects of its methanolic leaf extract, focusing on its antibacterial, antioxidant, antidiabetic, molecular docking, larvicidal and insecticidal properties. The extract is rich in phenols and flavonoids, containing 20 compounds identified through GC-MS analysis. The primary components include Hexadecanoic acid (29.31 %). FTIR analysis revealed the presence of functional groups such as alcohols, alkenes and amides. The extract demonstrated strong antibacterial activity, especially against Staphylococcus aureus and exhibited significant Antioxidant effects, achieving 60.27 % inhibition in the DPPH assay and 65.20 % inhibition in the ABTS assay. It also showed considerable Antidiabetic potential, inhibiting α-amylase (66.50 %) and α-glucosidase (61.12 %). Molecular docking studies with antidiabetic proteins (5NN8, 3W37) indicated promising interactions, suggesting potential therapeutic applications for diabetes. Additionally, the extract exhibited potent larvicidal and insecticidal properties. Overall, the leaf extract of I. chinensis showcases diverse biological activities, highlighting its potential as a valuable resource in medicinal research.
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