{"title":"凤仙花叶提取物的毒理学特征和治疗潜力:探索抗菌、抗氧化、降糖和杀虫特性","authors":"Dharmalingam Kirubakaran , Venugopal Krishnan","doi":"10.1016/j.prenap.2025.100238","DOIUrl":null,"url":null,"abstract":"<div><div><em>Impatiens chinensis</em>, a plant known for its traditional medicinal applications, has not been thoroughly investigated for its biological activities. This research delves into the chemical composition and biological effects of its methanolic leaf extract, focusing on its antibacterial, antioxidant, antidiabetic, molecular docking, larvicidal and insecticidal properties. The extract is rich in phenols and flavonoids, containing 20 compounds identified through GC-MS analysis. The primary components include Hexadecanoic acid (29.31 %). FTIR analysis revealed the presence of functional groups such as alcohols, alkenes and amides. The extract demonstrated strong antibacterial activity, especially against <em>Staphylococcus aureus</em> and exhibited significant Antioxidant effects, achieving 60.27 % inhibition in the DPPH assay and 65.20 % inhibition in the ABTS assay. It also showed considerable Antidiabetic potential, inhibiting α-amylase (66.50 %) and α-glucosidase (61.12 %). Molecular docking studies with antidiabetic proteins (5NN8, 3W37) indicated promising interactions, suggesting potential therapeutic applications for diabetes. Additionally, the extract exhibited potent larvicidal and insecticidal properties. Overall, the leaf extract of <em>I. chinensis</em> showcases diverse biological activities, highlighting its potential as a valuable resource in medicinal research.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100238"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Toxicological profile and therapeutic potentials of Impatiens chinensis leaf extract: Exploring antibacterial, antioxidant, antidiabetic and insecticidal properties\",\"authors\":\"Dharmalingam Kirubakaran , Venugopal Krishnan\",\"doi\":\"10.1016/j.prenap.2025.100238\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div><em>Impatiens chinensis</em>, a plant known for its traditional medicinal applications, has not been thoroughly investigated for its biological activities. This research delves into the chemical composition and biological effects of its methanolic leaf extract, focusing on its antibacterial, antioxidant, antidiabetic, molecular docking, larvicidal and insecticidal properties. The extract is rich in phenols and flavonoids, containing 20 compounds identified through GC-MS analysis. The primary components include Hexadecanoic acid (29.31 %). FTIR analysis revealed the presence of functional groups such as alcohols, alkenes and amides. The extract demonstrated strong antibacterial activity, especially against <em>Staphylococcus aureus</em> and exhibited significant Antioxidant effects, achieving 60.27 % inhibition in the DPPH assay and 65.20 % inhibition in the ABTS assay. It also showed considerable Antidiabetic potential, inhibiting α-amylase (66.50 %) and α-glucosidase (61.12 %). Molecular docking studies with antidiabetic proteins (5NN8, 3W37) indicated promising interactions, suggesting potential therapeutic applications for diabetes. Additionally, the extract exhibited potent larvicidal and insecticidal properties. Overall, the leaf extract of <em>I. chinensis</em> showcases diverse biological activities, highlighting its potential as a valuable resource in medicinal research.</div></div>\",\"PeriodicalId\":101014,\"journal\":{\"name\":\"Pharmacological Research - Natural Products\",\"volume\":\"7 \",\"pages\":\"Article 100238\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Natural Products\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950199725000989\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199725000989","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Toxicological profile and therapeutic potentials of Impatiens chinensis leaf extract: Exploring antibacterial, antioxidant, antidiabetic and insecticidal properties
Impatiens chinensis, a plant known for its traditional medicinal applications, has not been thoroughly investigated for its biological activities. This research delves into the chemical composition and biological effects of its methanolic leaf extract, focusing on its antibacterial, antioxidant, antidiabetic, molecular docking, larvicidal and insecticidal properties. The extract is rich in phenols and flavonoids, containing 20 compounds identified through GC-MS analysis. The primary components include Hexadecanoic acid (29.31 %). FTIR analysis revealed the presence of functional groups such as alcohols, alkenes and amides. The extract demonstrated strong antibacterial activity, especially against Staphylococcus aureus and exhibited significant Antioxidant effects, achieving 60.27 % inhibition in the DPPH assay and 65.20 % inhibition in the ABTS assay. It also showed considerable Antidiabetic potential, inhibiting α-amylase (66.50 %) and α-glucosidase (61.12 %). Molecular docking studies with antidiabetic proteins (5NN8, 3W37) indicated promising interactions, suggesting potential therapeutic applications for diabetes. Additionally, the extract exhibited potent larvicidal and insecticidal properties. Overall, the leaf extract of I. chinensis showcases diverse biological activities, highlighting its potential as a valuable resource in medicinal research.