抑郁症患者肾上腺体积测量

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-05-06 DOI:10.1016/j.jpsychires.2025.05.013

Leonard Stepansky , Richard Ruppel , Lisa Sommerfeld , Joy Kleiß , Kaan Türkan , Sebastian Arndt , Sebastian Bickelhaupt , Florian Knoll , Michael Uder , Matthias Stefan May

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引用次数: 0

摘要

目的先前的研究显示了抑郁症患者肾上腺体积（AGV）的矛盾结果，一些报告显着增大，而另一些则没有。本研究的目的是回顾性比较抑郁症患者肾上腺的CT图像分割与严格排除标准的对照组，以尽量减少混杂因素。方法纳入2012年至2022年间接受腹部CT检查的抑郁症（ICD-10: F32/33）患者，且无其他精神疾病。排除可能影响AGV的诊断。将31名抑郁症患者与31名没有抑郁症的对照组患者进行比较。在薄切片重建（≤1 mm）中手动分割AGV。结果抑郁组总AGV为6.78 (5.19 ~ 7.56)cm3，对照组为6.90 (5.54 ~ 10.05)cm3。经年龄、身高、体重调整后，两组AGV无显著差异。AGV与身高呈正相关(r = 0.41, p <；0.001)和体重(r = 0.52, p <；0.001)。男性AGV显著大于女性（p≤0.001），左侧AGV显著大于右侧AGV (p <；0.001)。自杀未遂后接受影像检查的抑郁组患者与对照组相比，显示出更大的总AGV，尽管没有统计学意义。结论本研究中精心挑选的抑郁症患者agv并未增加，这与之前的一些文献报道形成对比。需要进一步的多中心研究来确定潜在的影响因素，如自杀未遂。

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Adrenal gland volume measurement in depressed patients

Purpose

Prior studies have shown contradicting results regarding adrenal gland volume (AGV) in depressed patients, with some reporting significant enlargement and others not. The aim of this study was to retrospectively compare CT image segmentations of the adrenal glands in patients with depression to a control group with stringent exclusion criteria to minimize confounding factors.

Methods

We included patients diagnosed with depression (ICD-10: F32/33) who underwent abdominal CT imaging between 2012 and 2022 and did not have any other psychiatric disorders. Diagnoses that could potentially influence AGV were excluded. The resulting 31 depressed patients were compared to a matching control group of 31 patients without depression. The AGV was manually segmented in thin-sliced reconstructions (≤1 mm).

Results

Total AGV in the depressed group was 6.78 (5.19–7.56) cm³ compared to 6.90 (5.54–10.05) cm³ in the control group. There was no significant difference in AGV between the two groups after adjusting for age, height, and weight. A positive correlation was observed between AGV and height (r = 0.41, p < 0.001) and weight (r = 0.52, p < 0.001). Males showed significantly larger AGV than females (p ≤ 0.001), and left AGV was significantly larger than right AGV (p < 0.001). Patients within the depressed group who underwent imaging after a suicide attempt showed larger total AGV compared to the control group, though not statistically significant.

Conclusion

AGV is not increased in the well-selected cohort of depressed patients in this study, which contrasts with some previous reports in literature. Further multi-centric studies are required to identify potentially influencing factors such as attempted suicide.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;