{"title":"孕妇孕期钙摄入与青少年抑郁症状:九州冲绳母婴健康研究","authors":"Yoshihiro Miyake , Hitomi Okubo , Satoshi Sasaki , Keiko Tanaka","doi":"10.1016/j.jpsychires.2025.05.018","DOIUrl":null,"url":null,"abstract":"<div><div>To date, no studies have examined the relationship between maternal dietary intake during pregnancy and the risk of depressive symptoms during adolescence in their children. The current prebirth cohort study investigated the association between maternal calcium intake during pregnancy and the risk of depressive symptoms in adolescent children. Study subjects were 873 mother–child pairs. Maternal calcium intake during pregnancy was assessed using a self-administered diet history questionnaire. Adolescent depressive symptoms were defined as a 20-item Center for Epidemiologic Studies Depression Scale score of ≥16. The risk of depressive symptoms was 23.3 % among the 873 adolescents at 13 years of age. Compared with maternal calcium intake during pregnancy in the first quartile, intake in the fourth quartile was independently associated with a reduced risk of depressive symptoms in adolescents; however, the inverse exposure–response relationship was not statistically significant: the adjusted odd ratios (95 % confidence intervals) for depressive symptoms in adolescents in the first, second, third, and fourth quartiles of maternal calcium intake during pregnancy were 1 (reference), 0.63 (0.39−0.99), 0.91 (0.58−1.41), and 0.58 (0.36−0.93), respectively (<em>P</em> for trend = 0.10). The present study found that higher maternal calcium intake during pregnancy was inversely related to depressive symptoms in the adolescents at 13 years. This finding highlights the potential benefits of increasing maternal calcium intake during pregnancy as a means of preventing childhood depressive symptoms.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"187 ","pages":"Pages 80-84"},"PeriodicalIF":3.7000,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Maternal calcium intake during pregnancy and adolescent depressive symptoms: The Kyushu Okinawa Maternal and Child Health Study\",\"authors\":\"Yoshihiro Miyake , Hitomi Okubo , Satoshi Sasaki , Keiko Tanaka\",\"doi\":\"10.1016/j.jpsychires.2025.05.018\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>To date, no studies have examined the relationship between maternal dietary intake during pregnancy and the risk of depressive symptoms during adolescence in their children. The current prebirth cohort study investigated the association between maternal calcium intake during pregnancy and the risk of depressive symptoms in adolescent children. Study subjects were 873 mother–child pairs. Maternal calcium intake during pregnancy was assessed using a self-administered diet history questionnaire. Adolescent depressive symptoms were defined as a 20-item Center for Epidemiologic Studies Depression Scale score of ≥16. The risk of depressive symptoms was 23.3 % among the 873 adolescents at 13 years of age. Compared with maternal calcium intake during pregnancy in the first quartile, intake in the fourth quartile was independently associated with a reduced risk of depressive symptoms in adolescents; however, the inverse exposure–response relationship was not statistically significant: the adjusted odd ratios (95 % confidence intervals) for depressive symptoms in adolescents in the first, second, third, and fourth quartiles of maternal calcium intake during pregnancy were 1 (reference), 0.63 (0.39−0.99), 0.91 (0.58−1.41), and 0.58 (0.36−0.93), respectively (<em>P</em> for trend = 0.10). The present study found that higher maternal calcium intake during pregnancy was inversely related to depressive symptoms in the adolescents at 13 years. This finding highlights the potential benefits of increasing maternal calcium intake during pregnancy as a means of preventing childhood depressive symptoms.</div></div>\",\"PeriodicalId\":16868,\"journal\":{\"name\":\"Journal of psychiatric research\",\"volume\":\"187 \",\"pages\":\"Pages 80-84\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-05-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of psychiatric research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022395625003085\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of psychiatric research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022395625003085","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Maternal calcium intake during pregnancy and adolescent depressive symptoms: The Kyushu Okinawa Maternal and Child Health Study
To date, no studies have examined the relationship between maternal dietary intake during pregnancy and the risk of depressive symptoms during adolescence in their children. The current prebirth cohort study investigated the association between maternal calcium intake during pregnancy and the risk of depressive symptoms in adolescent children. Study subjects were 873 mother–child pairs. Maternal calcium intake during pregnancy was assessed using a self-administered diet history questionnaire. Adolescent depressive symptoms were defined as a 20-item Center for Epidemiologic Studies Depression Scale score of ≥16. The risk of depressive symptoms was 23.3 % among the 873 adolescents at 13 years of age. Compared with maternal calcium intake during pregnancy in the first quartile, intake in the fourth quartile was independently associated with a reduced risk of depressive symptoms in adolescents; however, the inverse exposure–response relationship was not statistically significant: the adjusted odd ratios (95 % confidence intervals) for depressive symptoms in adolescents in the first, second, third, and fourth quartiles of maternal calcium intake during pregnancy were 1 (reference), 0.63 (0.39−0.99), 0.91 (0.58−1.41), and 0.58 (0.36−0.93), respectively (P for trend = 0.10). The present study found that higher maternal calcium intake during pregnancy was inversely related to depressive symptoms in the adolescents at 13 years. This finding highlights the potential benefits of increasing maternal calcium intake during pregnancy as a means of preventing childhood depressive symptoms.
期刊介绍:
Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research:
(1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors;
(2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology;
(3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;