遗传多态性与牙釉质龋易感性的综合综述

IF 1 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2025-04-22 DOI:10.1016/j.genrep.2025.102235

Mehdi Akafzadeh , Bahar Bonakdar , Yasin Nazari , Atefe Ali Moradi , Shakiba Akbarian

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引用次数: 0

摘要

龋齿仍然是一项重大的全球公共卫生挑战，影响着数百万人，突出表明需要制定有效的预防战略。值得注意的是，遗传多态性，特别是单核苷酸多态性（snp），通过影响牙釉质形成、唾液组成和免疫反应，在个体对龋齿的易感性中起着关键作用。牙釉质龋是一个重要的公共卫生问题，受遗传和环境因素复杂相互作用的影响。这篇综合综述探讨了遗传多态性在牙釉质龋易感性中的关键作用。通过识别风险等位基因，牙科专业人员可以根据个人基因特征定制预防策略，包括定制氟化物治疗和饮食建议。这种有针对性的干预措施可以使患者采取更健康的行为，从而减少龋齿发病率。了解龋齿的遗传基础将促进研究和临床实践，导致更有效的预防策略和改善患者的结果。

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Genetic polymorphisms and enamel caries susceptibility: A comprehensive review

Dental caries remains a significant global public health challenge, affecting millions of individuals and highlighting the need for effective prevention strategies. Notably, genetic polymorphisms, particularly single nucleotide polymorphisms (SNPs), play a critical role in individual susceptibility to caries by influencing enamel formation, salivary composition, and immune responses. Enamel caries remains a significant public health concern, influenced by a complex interplay of genetic and environmental factors. This comprehensive review explores the critical role of genetic polymorphisms in susceptibility to enamel caries. By identifying risk alleles, dental professionals can tailor preventive strategies, including customized fluoride treatments and dietary recommendations, to individual genetic profiles. Such targeted interventions can empower patients to adopt healthier behaviors, thereby reducing caries incidence. Understanding the genetic underpinnings of dental caries will advance both research and clinical practice, leading to more effective prevention strategies and improved patient outcomes.

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.