Helja凝集素抑制白色念珠菌吞噬并诱导树突状细胞的促炎反应

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2025-05-09 DOI:10.1016/j.phymed.2025.156637

Maia Chop , Marianela Del Rio , Melisa B. Radicioni , Ágata C. Cevey , Marco J. Hernández-Chávez , Héctor M. Mora-Montes , Mariana Regente , Christian Rodriguez Rodrigues

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引用次数: 0

摘要

植物凝集素因其抗菌和免疫调节特性以及在控制感染性疾病和炎症性疾病方面的潜在治疗应用而受到关注。目的研究向日葵凝集素Helja对白色念珠菌吞噬的影响及其对树突状细胞的免疫调节作用，探索控制感染性疾病的免疫治疗策略。结果Helja凝集素可以调节和抑制骨髓源树突状细胞对白色假丝酵母的吞噬，通过上调CD86和MHC II类共刺激分子诱导树突状细胞成熟，促进活性氧和一氧化氮的生成，增加促炎细胞因子TNF-α、IL-12和TGF-β的产生。在外周血单核细胞中也观察到这种细胞因子谱，其中与凝集素预先孵育的Helja和白色念珠菌促进了TNF-α和IL-1β的释放。结论Helja凝集素具有调节树突状细胞和细胞因子反应的潜力，提示其具有免疫调节作用，提示该植物凝集素作为潜在的治疗剂具有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Helja lectin inhibits Candida albicans phagocytosis and induces pro-inflammatory responses in dendritic cells

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Helja lectin inhibits Candida albicans phagocytosis and induces pro-inflammatory responses in dendritic cells

Background

Plant lectins have gained attention for their antimicrobial and immunomodulatory properties and potential therapeutic applications in controlling infectious diseases and inflammatory disorders.

Purpose

This study focused on the effect of the sunflower lectin Helja on Candida albicans phagocytosis and its immunomodulatory effects on dendritic cells, to explore alternative immunotherapeutic strategies to control infectious diseases.

Results

Here, we showed that Helja lectin opsonizes and inhibits C. albicans phagocytosis by bone marrow-derived dendritic cells, induces dendritic cell maturation by upregulating co-stimulatory molecules, such as CD86 and MHC class II, promotes reactive oxygen species and nitric oxide generation and increases the production of the pro-inflammatory cytokines TNF-α, IL-12, and TGF-β. This cytokine profile was also observed in peripheral blood mononuclear cells, where Helja and C. albicans pre-incubated with the lectin promoted the release of TNF-α and IL-1β.

Conclusion

These findings suggest that Helja lectin has the potential to modulate dendritic cells and cytokine responses, indicating its role in immune regulation and underscoring the significance of this plant lectin as a potential therapeutic agent.

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.