通过相分离调节RIG-I活性揭示了新的治疗机会

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-05-09 DOI:10.1038/s41556-025-01656-3

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引用次数: 0

摘要

病毒感染后，RIG-I形成二硫化物连接的低聚物，这些低聚物不易降解，并且能够进入液体状凝聚物，这是RIG-I介导的I型干扰素信号传导刺激所必需的。RIG-I激动剂和拮抗剂分别增强或阻止二硫化物连接的RIG-I寡聚物的形成，证实了这种机制对RIG-I功能至关重要，可以用来增强抗病毒免疫或抑制过度活跃的RIG-I引起的自身免疫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Regulation of RIG-I activity by phase separation reveals new therapeutic opportunities

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Regulation of RIG-I activity by phase separation reveals new therapeutic opportunities

After virus infection, RIG-I forms disulfide-linked oligomers that are resistant to degradation and able to enter liquid-like condensates, which is necessary for RIG-I-mediated stimulation of type I interferon signalling. RIG-I agonists and antagonists that enhance or prevent formation of disulfide-linked RIG-I oligomers, respectively, confirm that this mechanism is crucial for RIG-I function and could be harnessed to boost antiviral immunity or suppress autoimmunity caused by hyperactive RIG-I.

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology