Anatomy-Aware Deep Unrolling for Task-Oriented Acceleration of Multi-Contrast MRI.

Multi-contrast magnetic resonance imaging (MC-MRI) plays a crucial role in clinical practice. However, its performance is hindered by long scanning times and the isolation between image acquisition and downstream clinical diagnoses/treatments. Despite the activated research on accelerated MC-MRI, few existing studies prioritize personalized imaging tailored to individual patient characteristics and clinical needs. That is, the current approach often aims to enhance overall image quality, disregarding the specific pathologies or anatomical regions that are of particular interest to clinicians. To tackle this challenge, we propose an anatomy-aware unrolling-based deep network, dubbed as A2MC-MRI, offering promising interpretability and learning capacity for fast MC-MRI catering to downstream clinical needs. The network is unfolded from the iterative algorithm designed for a task-oriented MC-MRI reconstruction model. Specifically, to enhance concurrent MC-MRI of specific targets of interest (TOIs), the model integrates a learnable group sparsity with an anatomyaware denoising prior. Within the anatomy-aware denoising prior, a segmentation network is involved to provide critical location information for TOI-enhanced denoising. Finally, such an unrolled network is jointly learned with k-space sampling patterns for task-oriented MC-MR reconstruction. Comprehensive evaluations on two public benchmarks as well as an in-house dataset demonstrate that our A2MCMRI led to state-of-the-art performance in MC-MRI reconstruction under high acceleration rates, featuring notable enhancements in TOI imaging quality. The code will be available at https://github.com/ladderlab-xjtu/A2MC-MRI.