{"title":"直肠神经鞘瘤样/Verocay体突出型良性平滑肌瘤1例报告","authors":"Alan King Lun Liu, Joanne Chapman","doi":"10.1016/j.mpdhp.2025.03.008","DOIUrl":null,"url":null,"abstract":"<div><div>Verocay bodies are typically found in schwannoma and are often heralded as classical features of the lesion but they are not pathognomonic and can occasionally be found in other neoplasms, including leiomyomas and gastrointestinal stromal tumours (GIST) within the gastrointestinal (GI) tract. Hence, it is important to bear this differential diagnosis in mind and utilize an immunohistochemical panel to aid with the diagnosis. Here we present an unusual case of a 62-year-old male with an incidental rectal mass found on digital rectal examination upon presenting to urology with increased lower urinary tract symptoms. Histology of the rectal mass showed a spindle cell proliferation with prominent Verocay bodies seen throughout the specimen. Immunohistochemistry demonstrated that the tumour was positive for actin and desmin, negative for S100, DOG1, CD34 and CD117 (c-KIT), confirming it to being a Verocay body-prominent leiomyoma.</div></div>","PeriodicalId":39961,"journal":{"name":"Diagnostic Histopathology","volume":"31 5","pages":"Pages 307-309"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A case report on a schwannoma-like/Verocay body-prominent benign leiomyoma in the rectum\",\"authors\":\"Alan King Lun Liu, Joanne Chapman\",\"doi\":\"10.1016/j.mpdhp.2025.03.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Verocay bodies are typically found in schwannoma and are often heralded as classical features of the lesion but they are not pathognomonic and can occasionally be found in other neoplasms, including leiomyomas and gastrointestinal stromal tumours (GIST) within the gastrointestinal (GI) tract. Hence, it is important to bear this differential diagnosis in mind and utilize an immunohistochemical panel to aid with the diagnosis. Here we present an unusual case of a 62-year-old male with an incidental rectal mass found on digital rectal examination upon presenting to urology with increased lower urinary tract symptoms. Histology of the rectal mass showed a spindle cell proliferation with prominent Verocay bodies seen throughout the specimen. Immunohistochemistry demonstrated that the tumour was positive for actin and desmin, negative for S100, DOG1, CD34 and CD117 (c-KIT), confirming it to being a Verocay body-prominent leiomyoma.</div></div>\",\"PeriodicalId\":39961,\"journal\":{\"name\":\"Diagnostic Histopathology\",\"volume\":\"31 5\",\"pages\":\"Pages 307-309\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diagnostic Histopathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1756231725000398\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic Histopathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1756231725000398","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A case report on a schwannoma-like/Verocay body-prominent benign leiomyoma in the rectum
Verocay bodies are typically found in schwannoma and are often heralded as classical features of the lesion but they are not pathognomonic and can occasionally be found in other neoplasms, including leiomyomas and gastrointestinal stromal tumours (GIST) within the gastrointestinal (GI) tract. Hence, it is important to bear this differential diagnosis in mind and utilize an immunohistochemical panel to aid with the diagnosis. Here we present an unusual case of a 62-year-old male with an incidental rectal mass found on digital rectal examination upon presenting to urology with increased lower urinary tract symptoms. Histology of the rectal mass showed a spindle cell proliferation with prominent Verocay bodies seen throughout the specimen. Immunohistochemistry demonstrated that the tumour was positive for actin and desmin, negative for S100, DOG1, CD34 and CD117 (c-KIT), confirming it to being a Verocay body-prominent leiomyoma.
期刊介绍:
This monthly review journal aims to provide the practising diagnostic pathologist and trainee pathologist with up-to-date reviews on histopathology and cytology and related technical advances. Each issue contains invited articles on a variety of topics from experts in the field and includes a mini-symposium exploring one subject in greater depth. Articles consist of system-based, disease-based reviews and advances in technology. They update the readers on day-to-day diagnostic work and keep them informed of important new developments. An additional feature is the short section devoted to hypotheses; these have been refereed. There is also a correspondence section.