拉丁美洲和加勒比地区戊型肝炎患病率：系统回顾和荟萃分析

IF 3.9 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Public Health Pub Date : 2025-05-09 DOI:10.1016/j.puhe.2025.105745

Mariana Cavalheiro Magri , Caroline Manchiero , Bianca Peixoto Dantas , Wanderley Marques Bernardo , Edson Abdala , Fátima Mitiko Tengan

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引用次数: 0

摘要

目的通过检测戊型肝炎病毒（HEV） IgG抗体的存在，估计拉丁美洲和加勒比地区戊型肝炎病毒（HEV）感染的流行情况。研究设计：系统回顾和荟萃分析。方法系统检索Medline、Lilacs和Embase数据库，选择符合PRISMA声明的81项研究，共38,951人。采用随机效应模型进行分析。数据分析考虑了研究队列和地理位置。结果LAC地区戊型肝炎患病率为0% ~ 36%，总患病率为9.0%，具有重要的异质性（I2 = 97.3%）。亚组荟萃分析显示，戊型肝炎在普通人群中的患病率为9.0%，在献血者中为6.0%，在农村人群中为9.0%，在职业接触猪人群中为21.0%，在孕妇中为9.0%，在免疫功能低下人群中为7.0%，在慢性肝病患者中为12.0%，在急性肝炎患者中为9.0%。根据地理位置，戊型肝炎的患病率在阿根廷为7.0%，玻利维亚为16.0%，巴西为7.0%，哥伦比亚为17.0%，古巴为24.0%。生成的漏斗图不对称，根据Egger （p = 0.000）和Begg （p = 0.003）检验，存在偏倚的证据。在分析中，仅包括质量评分为5分的研究，戊型肝炎的患病率为8.0%。在分析样本量大于200和500的研究时，我们分别确定了8.0%和7.0%的患病率。结论本综述所获得的信息提示了目前戊型肝炎在拉美和加勒比地区的综合流行情况，可作为规划预防策略的工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Prevalence of hepatitis E in Latin America and the Caribbean: A systematic review and meta-analysis

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Prevalence of hepatitis E in Latin America and the Caribbean: A systematic review and meta-analysis

Objective

To estimate the prevalence of hepatitis E virus (HEV) infection by the presence of anti-HEV IgG antibodies in Latin America and the Caribbean (LAC).

Study design

Systematic review and meta-analysis.

Methods

Systematic searches were conducted in the Medline, Lilacs and Embase databases, selecting 81 studies comprising 38,951 individuals in accordance with the PRISMA Statement. Analyses were performed by using the random-effects model. Data analysis considered study cohort and geographic location.

Results

The prevalence of hepatitis E in LAC ranged from 0 % to 36 % and the overall prevalence was 9.0 %, with important heterogeneity (I² = 97.3 %). Meta-analysis of subgroups showed prevalence of hepatitis E of 9.0 % in the general population, 6.0 % in blood donors, 9.0 % in rural population, 21.0 % in occupational exposure to pigs, 9.0 % in pregnant women, 7.0 % in immunocompromised individuals, 12.0 % in individuals with chronic liver disease and 9.0 % in individuals with acute hepatitis. According to geographic location, the prevalence of hepatitis E was 7.0 % in Argentina, 16.0 % in Bolivia, 7.0 % in Brazil, 17.0 % in Colombia and 24.0 % in Cuba. The generated funnel plot appeared asymmetric, with evidence of bias according to Egger (p = 0.000) and Begg (p = 0.003) tests. In the analysis, which included only studies with a quality score >5, the prevalence of hepatitis E was 8.0 %. When analysing studies with sample sizes greater than 200 and 500, we identified prevalences of 8.0 % and 7.0 %, respectively.

Conclusions

The information obtained in this review warns about the current consolidated prevalence of hepatitis E in LAC, which can be a tool for planning prevention strategies.

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来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.