水凝胶组织胶：粘接策略及应用

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-04-30 DOI:10.1016/j.colsurfb.2025.114755

Boyuan An , Haohao Cui , Mengke Wang , Zhanrong Li , Jingguo Li

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引用次数: 0

摘要

由于水凝胶组织粘接剂操作简单，具有生物相容性和多功能整合能力，因此它已成为传统伤口缝合方法（如缝合线和订书钉）的一种有希望的替代方法。然而，复杂多变的组织微环境和动态粘附表面仍然对胶粘剂，特别是天然聚合物基胶粘剂的实际粘附性能提出了挑战。此外，为了扩大粘接剂在生物医学领域的应用，迫切需要通过组合物设计、粘连机理研究和生物效应开发来进一步提高组织粘连性能。本文综述了胶粘剂的粘接性能及其在生物医学领域的应用。介绍了粘接-内聚平衡、粘接失效的形式、提高粘接的方法和各种界面粘接机制。综述了组织粘接剂在皮肤、心脏、胃、肝脏和角膜等方面的应用。最后，对新一代多功能、强附着力的组织胶粘剂进行了展望，希望能对该领域的工作人员有所启发。

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Hydrogel tissue adhesive: Adhesion strategy and application

Hydrogel tissue adhesives have emerged as a promising alternative to conventional wound closure methods such as sutures and staples due to their operational simplicity demonstrated biocompatibility and capacity for multifunctional integration. However, complex and variable tissue microenvironments and dynamic adhesion surfaces still challenge the actual adhesion performance of adhesives, especially natural polymer-based adhesives. In addition, to expand the application of adhesives in biomedical fields, there is an urgent need to further improve tissue adhesion performance through composition design, adhesion mechanism research and bioeffect development. This review focuses on the adhesive properties of adhesives and their applications in biomedical fields. Adhesion-cohesion equilibria, forms of adhesion failure, methods for improving cohesion and various interfacial adhesion mechanisms are presented. Moreover, practical biomedical applications of tissue adhesives are reviewed, focusing on skin, heart, stomach, liver, and cornea. Finally, this review looks ahead to a new generation of multi-functional, strong adhesion tissue adhesives, in the hope of providing inspiration to those working in the field.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.