Cu-MOF在坡缕石中增强过氧化物酶样Cu2O/NPC的抗菌作用

IF 5.3 2区地球科学 Q2 CHEMISTRY, PHYSICAL

Applied Clay Science Pub Date : 2025-05-08 DOI:10.1016/j.clay.2025.107850

Cuicui Liang , Fei Zha , Xiaohua Tang , Xiaojun Guo , Haifeng Tian , Yue Chang

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引用次数: 0

摘要

抗生素的滥用导致各种耐药细菌的出现，对人类生命构成严重威胁。迫切需要新的抗微生物策略。本文以Cu-MOF衍生的Cu2O/纳米孔碳（Cu2O/NPC）为原料，在坡长石（Pal）存在下，采用热解-蚀刻-热解策略制备了Cu2O/NPC/Pal过氧化物酶样酶材料。Cu2O/NPC/Pal可催化H2O2生成·O2−，引起细菌氧化应激和细胞膜损伤。对金黄色葡萄球菌和铜绿假单胞菌的抑菌率分别为98.99%和92.70%。此外，Cu2O/NPC/Pal能有效促进谷胱甘肽的氧化和胞内消耗。在Cu2O/NPC中引入Pal，显著增强了Cu2O/NPC的结合亲和力，形成了一个高浓度的底物微环境。该研究为碳基金属氧化物纳米材料与矿物基材料结合合成增强过氧化物类活性的抗菌应用提供了热解策略。

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Enhanced antimicrobics of peroxidase-like Cu2O/NPC from Cu-MOF presented in palygorskite

The misuse of antibiotics leads to the emergence of a variety of drug-resistant bacteria, which poses a serious threat to human life. Novel antimicrobial strategies are urgently needed. Herein, peroxidase-like enzyme material of Cu₂O/NPC/Pal was prepared from Cu₂O/nanoporous carbon (Cu₂O/NPC) derived from Cu-MOF in the presence of palygorskite (Pal) by the pyrolysis-etching-pyrolysis strategy. Cu₂O/NPC/Pal could catalyze the production of ·O₂⁻ from H₂O₂ to cause the oxidative stress and cell membrane damage to bacteria. The antibacterial rates against Staphylococcus aureus and Pseudomonas aeruginosa reached 98.99 % and 92.70 %, respectively. In addition, Cu₂O/NPC/Pal can promote the oxidation of glutathione and the consumption of intracellular effectively. Introduction of Pal into Cu₂O/NPC significantly enhances the binding affinity and forms a highly concentrated substrate microenvironment. The study provided the pyrolysis strategy for the synthesis of carbon-based metal oxide nanomaterials in combination with mineral-based materials for the enhancement of peroxide-like activity in antimicrobial application.

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来源期刊

Applied Clay Science 地学-矿物学

CiteScore

10.30

自引率

10.70%

发文量

289

审稿时长

39 days

期刊介绍： Applied Clay Science aims to be an international journal attracting high quality scientific papers on clays and clay minerals, including research papers, reviews, and technical notes. The journal covers typical subjects of Fundamental and Applied Clay Science such as: • Synthesis and purification • Structural, crystallographic and mineralogical properties of clays and clay minerals • Thermal properties of clays and clay minerals • Physico-chemical properties including i) surface and interface properties; ii) thermodynamic properties; iii) mechanical properties • Interaction with water, with polar and apolar molecules • Colloidal properties and rheology • Adsorption, Intercalation, Ionic exchange • Genesis and deposits of clay minerals • Geology and geochemistry of clays • Modification of clays and clay minerals properties by thermal and physical treatments • Modification by chemical treatments with organic and inorganic molecules(organoclays, pillared clays) • Modification by biological microorganisms. etc...