苯并恶唑和亚砜的一锅合成：二芳基亚砜的完全利用

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-04-29 DOI:10.1021/acs.joc.5c0027410.1021/acs.joc.5c00274

Chuntao Zhong, Guangcai Qu, Jingdi Wang, Baoshan Xu, Benqiang Cui*, Yanhui Shi* and Changsheng Cao*,

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引用次数: 0

摘要

通过钯催化二芳基亚砜与苯并恶唑的交叉偶联，用不同的亲电试剂捕获剩余的亚砜阴离子，在一锅法中合成了2-芳基苯并恶唑和芳基亚砜衍生物。该反应包括C-S和C-H键的激活以及C-C和C-S键的形成。该协议允许广泛的基板范围，功能组公差和可扩展性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

One-Pot Synthesis of Benzoxazoles and Sulfoxides: Complete Utilization of Diaryl Sulfoxides

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One-Pot Synthesis of Benzoxazoles and Sulfoxides: Complete Utilization of Diaryl Sulfoxides

Synthesis of 2-aryl benzoxazoles and aryl sulfoxide derivatives in a one-pot process has been developed via the palladium-catalyzed cross-coupling of diaryl sulfoxides with benzoxazoles, followed by trapping the remaining sulfenate anions with different electrophilic reagents. The reaction involves the C–S and C–H bond activation and the C–C and C–S bond formation. The protocol allows a broad scope of substrates, functional group tolerance, and scalability.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.