Tim Du, Anada Silva, Kelly B. Choi, Cassandra Lybeck, George R. Golding, Romeo Hizon, Sean Ahmed, Nicole Anderson, Suzanne Bakai-Anderson, Blanda Chow, Ian Davis, Meghan Engbretson, Gerald A. Evans, Charles Frenette, Matthew Garrod, Jennie Johnstone, Kevin C. Katz, Pamela Kibsey, Joanne M. Langley, Jenine Leal, Jenna Leamon, Bonita E. Lee, Diane Lee, Yves Longtin, Dominik Mertz, Jessica Minion, Ericka Oates, Michelle Science, Jocelyn A. Srigley, Kathryn N. Suh, Nisha Thampi, Reena Titoria, Kristen Versluys, Alice Wong, Jeannette L. Comeau, Susy S. Hota
{"title":"加拿大2015-2022年成人和儿童医疗保健相关和社区相关艰难梭菌感染的特征","authors":"Tim Du, Anada Silva, Kelly B. Choi, Cassandra Lybeck, George R. Golding, Romeo Hizon, Sean Ahmed, Nicole Anderson, Suzanne Bakai-Anderson, Blanda Chow, Ian Davis, Meghan Engbretson, Gerald A. Evans, Charles Frenette, Matthew Garrod, Jennie Johnstone, Kevin C. Katz, Pamela Kibsey, Joanne M. Langley, Jenine Leal, Jenna Leamon, Bonita E. Lee, Diane Lee, Yves Longtin, Dominik Mertz, Jessica Minion, Ericka Oates, Michelle Science, Jocelyn A. Srigley, Kathryn N. Suh, Nisha Thampi, Reena Titoria, Kristen Versluys, Alice Wong, Jeannette L. Comeau, Susy S. Hota","doi":"10.3201/eid3106.250182","DOIUrl":null,"url":null,"abstract":"<p>We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) <em>Clostridioides difficile</em> infection (CDI) among adult and pediatric patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015–2022. Of 30,824 reported CDI cases, 94.9% (29,250/30,824) were among adult (73.2% HA; 26.8% CA) and 5.1% (1,574/30,824) pediatric (77.6% HA; 22.4% CA) patients. During the study period, adult HA CDI rates decreased by 19.9% and CA CDI rates remained stable; pediatric HA CDI rates decreased by 29.6% and CA CDI decreased by 58.3%. Ribotype (RT) 106 was most common among both groups and replaced RT027 as the predominant strain type. RT027 was most associated with adult patients, HA acquisition, severe CDI, and severe outcomes. Moxifloxacin resistance was higher in adult than pediatric cases; clindamycin and rifampin resistance rates were similar between groups. Continued national surveillance is integral to understanding the epidemiology of adult and pediatric CDI in Canada and informing prevention efforts.</p>","PeriodicalId":11595,"journal":{"name":"Emerging Infectious Diseases","volume":"142 1","pages":""},"PeriodicalIF":7.2000,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Characterization of Adult and Pediatric Healthcare-Associated and Community-Associated Clostridioides difficile Infections, Canada, 2015–2022\",\"authors\":\"Tim Du, Anada Silva, Kelly B. Choi, Cassandra Lybeck, George R. Golding, Romeo Hizon, Sean Ahmed, Nicole Anderson, Suzanne Bakai-Anderson, Blanda Chow, Ian Davis, Meghan Engbretson, Gerald A. Evans, Charles Frenette, Matthew Garrod, Jennie Johnstone, Kevin C. Katz, Pamela Kibsey, Joanne M. Langley, Jenine Leal, Jenna Leamon, Bonita E. Lee, Diane Lee, Yves Longtin, Dominik Mertz, Jessica Minion, Ericka Oates, Michelle Science, Jocelyn A. Srigley, Kathryn N. Suh, Nisha Thampi, Reena Titoria, Kristen Versluys, Alice Wong, Jeannette L. Comeau, Susy S. Hota\",\"doi\":\"10.3201/eid3106.250182\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) <em>Clostridioides difficile</em> infection (CDI) among adult and pediatric patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015–2022. Of 30,824 reported CDI cases, 94.9% (29,250/30,824) were among adult (73.2% HA; 26.8% CA) and 5.1% (1,574/30,824) pediatric (77.6% HA; 22.4% CA) patients. During the study period, adult HA CDI rates decreased by 19.9% and CA CDI rates remained stable; pediatric HA CDI rates decreased by 29.6% and CA CDI decreased by 58.3%. Ribotype (RT) 106 was most common among both groups and replaced RT027 as the predominant strain type. RT027 was most associated with adult patients, HA acquisition, severe CDI, and severe outcomes. Moxifloxacin resistance was higher in adult than pediatric cases; clindamycin and rifampin resistance rates were similar between groups. 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Characterization of Adult and Pediatric Healthcare-Associated and Community-Associated Clostridioides difficile Infections, Canada, 2015–2022
We investigated epidemiologic and molecular characteristics of healthcare-associated (HA) and community-associated (CA) Clostridioides difficile infection (CDI) among adult and pediatric patients in Canadian Nosocomial Infection Surveillance Program hospitals during 2015–2022. Of 30,824 reported CDI cases, 94.9% (29,250/30,824) were among adult (73.2% HA; 26.8% CA) and 5.1% (1,574/30,824) pediatric (77.6% HA; 22.4% CA) patients. During the study period, adult HA CDI rates decreased by 19.9% and CA CDI rates remained stable; pediatric HA CDI rates decreased by 29.6% and CA CDI decreased by 58.3%. Ribotype (RT) 106 was most common among both groups and replaced RT027 as the predominant strain type. RT027 was most associated with adult patients, HA acquisition, severe CDI, and severe outcomes. Moxifloxacin resistance was higher in adult than pediatric cases; clindamycin and rifampin resistance rates were similar between groups. Continued national surveillance is integral to understanding the epidemiology of adult and pediatric CDI in Canada and informing prevention efforts.
期刊介绍：
Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination.
Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.
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