{"title":"相位角是普通人群中肌肉减少症和认知障碍的一个潜在的新的早期标志","authors":"Kentaro Ikeue, Hisashi Kato, Masashi Tanaka, Hajime Yamakage, Sayaka Kato, Masayo Iwasa, Kan Oishi, Yuiko Yamamoto, Megumi Kanasaki, Izuru Masuda, Kojiro Ishii, Noriko Satoh-Asahara","doi":"10.1002/jcsm.13820","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Sarcopenia is associated with an increased risk for dementia. This study aimed to elucidate the relationship between sarcopenia-related indices and cognitive decline in the general population.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This was a cross-sectional study involving 263 participants (163 men with a median age of 60 years [interquartile range = 53–70] and 100 women with a median age of 58 years [interquartile range = 49–68]) who underwent a general health examination. Sarcopenia-related indices included appendicular skeletal muscle mass (ASM)/height<sup>2</sup>, ASM/body mass index, handgrip strength (HGS), HGS/upper extremity skeletal muscle mass and phase angle (PhA). We examined the associations between these indices and cognitive function using the Japanese version of the Montreal Cognitive Assessment (MoCA-J).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Higher PhA, an indicator of muscle quality, was associated with a lower risk of mild cognitive impairment (MCI) in women (adjusted odds ratio = 0.28 [95% confidence interval, 0.10–0.78], <i>p</i> = 0.014), whereas the other sarcopenia-related indices showed no significant association with MCI in both sexes. The PhA of women was positively associated with the MoCA-J scores (<i>β</i> = 0.27, <i>p</i> = 0.005). Moreover, the PhA of women showed a positive correlation with cognitive subdomains, including memory (<i>r</i> = 0.22, <i>p</i> = 0.031), which is one of the earliest manifestations of cognitive impairment. The PhA in men was also positively correlated with memory (<i>r</i> = 0.24, <i>p</i> = 0.002).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>PhA is a potentially novel index for detecting the risk of sarcopenia and cognitive decline in the general population.</p>\n </section>\n </div>","PeriodicalId":48911,"journal":{"name":"Journal of Cachexia Sarcopenia and Muscle","volume":"16 3","pages":""},"PeriodicalIF":9.4000,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcsm.13820","citationCount":"0","resultStr":"{\"title\":\"Phase Angle Is a Potential Novel Early Marker for Sarcopenia and Cognitive Impairment in the General Population\",\"authors\":\"Kentaro Ikeue, Hisashi Kato, Masashi Tanaka, Hajime Yamakage, Sayaka Kato, Masayo Iwasa, Kan Oishi, Yuiko Yamamoto, Megumi Kanasaki, Izuru Masuda, Kojiro Ishii, Noriko Satoh-Asahara\",\"doi\":\"10.1002/jcsm.13820\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Sarcopenia is associated with an increased risk for dementia. This study aimed to elucidate the relationship between sarcopenia-related indices and cognitive decline in the general population.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This was a cross-sectional study involving 263 participants (163 men with a median age of 60 years [interquartile range = 53–70] and 100 women with a median age of 58 years [interquartile range = 49–68]) who underwent a general health examination. Sarcopenia-related indices included appendicular skeletal muscle mass (ASM)/height<sup>2</sup>, ASM/body mass index, handgrip strength (HGS), HGS/upper extremity skeletal muscle mass and phase angle (PhA). We examined the associations between these indices and cognitive function using the Japanese version of the Montreal Cognitive Assessment (MoCA-J).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Higher PhA, an indicator of muscle quality, was associated with a lower risk of mild cognitive impairment (MCI) in women (adjusted odds ratio = 0.28 [95% confidence interval, 0.10–0.78], <i>p</i> = 0.014), whereas the other sarcopenia-related indices showed no significant association with MCI in both sexes. The PhA of women was positively associated with the MoCA-J scores (<i>β</i> = 0.27, <i>p</i> = 0.005). Moreover, the PhA of women showed a positive correlation with cognitive subdomains, including memory (<i>r</i> = 0.22, <i>p</i> = 0.031), which is one of the earliest manifestations of cognitive impairment. 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引用次数: 0
摘要
背景：骨骼肌减少症与痴呆风险增加有关。本研究旨在阐明一般人群中肌少症相关指标与认知能力下降之间的关系。方法本研究是一项横断面研究，涉及263名参与者（163名男性，中位年龄为60岁[四分位数范围为53-70]）和100名女性，中位年龄为58岁[四分位数范围为49-68])，他们接受了一般健康检查。肌少症相关指标包括：阑尾骨骼肌质量(ASM)/身高2、ASM/体重指数、握力（HGS）、HGS/上肢骨骼肌质量和相位角（PhA）。我们使用日本版的蒙特利尔认知评估（MoCA-J）检查了这些指标与认知功能之间的关系。结果较高的PhA（肌肉质量指标）与女性轻度认知障碍（MCI）的风险较低相关（校正优势比= 0.28[95%置信区间，0.10-0.78],p = 0.014），而其他与肌肉减少症相关的指标在两性中均与MCI无显著相关性。女性的PhA与MoCA-J评分呈正相关（β = 0.27, p = 0.005）。此外，女性的PhA与认知子域呈正相关，包括记忆（r = 0.22, p = 0.031），这是认知障碍的最早表现之一。男性的PhA也与记忆力呈正相关（r = 0.24, p = 0.002）。结论PhA是一种潜在的检测普通人群肌肉减少症和认知能力下降风险的新指标。
Phase Angle Is a Potential Novel Early Marker for Sarcopenia and Cognitive Impairment in the General Population
Background
Sarcopenia is associated with an increased risk for dementia. This study aimed to elucidate the relationship between sarcopenia-related indices and cognitive decline in the general population.
Methods
This was a cross-sectional study involving 263 participants (163 men with a median age of 60 years [interquartile range = 53–70] and 100 women with a median age of 58 years [interquartile range = 49–68]) who underwent a general health examination. Sarcopenia-related indices included appendicular skeletal muscle mass (ASM)/height2, ASM/body mass index, handgrip strength (HGS), HGS/upper extremity skeletal muscle mass and phase angle (PhA). We examined the associations between these indices and cognitive function using the Japanese version of the Montreal Cognitive Assessment (MoCA-J).
Results
Higher PhA, an indicator of muscle quality, was associated with a lower risk of mild cognitive impairment (MCI) in women (adjusted odds ratio = 0.28 [95% confidence interval, 0.10–0.78], p = 0.014), whereas the other sarcopenia-related indices showed no significant association with MCI in both sexes. The PhA of women was positively associated with the MoCA-J scores (β = 0.27, p = 0.005). Moreover, the PhA of women showed a positive correlation with cognitive subdomains, including memory (r = 0.22, p = 0.031), which is one of the earliest manifestations of cognitive impairment. The PhA in men was also positively correlated with memory (r = 0.24, p = 0.002).
Conclusions
PhA is a potentially novel index for detecting the risk of sarcopenia and cognitive decline in the general population.
期刊介绍：
The Journal of Cachexia, Sarcopenia and Muscle is a peer-reviewed international journal dedicated to publishing materials related to cachexia and sarcopenia, as well as body composition and its physiological and pathophysiological changes across the lifespan and in response to various illnesses from all fields of life sciences. The journal aims to provide a reliable resource for professionals interested in related research or involved in the clinical care of affected patients, such as those suffering from AIDS, cancer, chronic heart failure, chronic lung disease, liver cirrhosis, chronic kidney failure, rheumatoid arthritis, or sepsis.
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