封面：新型磺胺- sydnone复合物：抗炎作用、抗sars - cov -2活性、人血清白蛋白相互作用和硅分析的互补洞察（ChemMedChem 9/2025）

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-05-07 DOI:10.1002/cmdc.202580901

Igor Resendes Barbosa, Mayara Alves Amorim, Vitor Hélio de Souza Oliveira, Eunice André, Guilherme Pereira Guedes, Otávio Augusto Chaves, Carlos Serpa, Natalia Fintelman-Rodrigues, Carolina Q. Sacramento, Thiago Moreno L. Souza, Carlos Mauricio R. Sant'Anna, Aurea Echevarria

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引用次数: 0

摘要

设计并合成了新型磺胺-赛德酮复合物，作为潜在的抗sars - cov -2和抗炎药物。基于细胞的实验表明，与syd酮杂环核心连接的苯基环相关的对位磺胺片段比间位取代具有更好的抗病毒效力，通过非竞争方式靶向SARS-CoV-2的主要蛋白酶（Mpro）。更多细节可以在10.1002/cmdc中找到。202400697 Aurea Echevarria及其同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Front Cover: Novel Sulfonamide-Sydnone Hybrids: Complementary Insight into Anti-Inflammatory Action, Anti-SARS-CoV-2 Activity, Human Serum Albumin Interaction, and in silico Analysis (ChemMedChem 9/2025)

查看原文本刊更多论文

Novel sulfonamide-sydnone hybrids are designed and synthesized as potential anti-SARS-CoV-2 and anti-inflammatory. Cell-based assays indicate that the sulfonamide moiety in para-position related to the phenyl ring attached to the sydnone heterocycle core have better antiviral potency than the meta-position substitution, targeting the main protease (M^pro) of SARS-CoV-2 via a non-competitive way. More details can be found in article 10.1002/cmdc.202400697 by Aurea Echevarria and co-workers.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.