异己酯的合成路线及应用领域:相关工业化合物的综合展望

Daria Armani
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引用次数: 0

摘要

异己体是一类可以用简单的方法从天然来源获得的化合物,具有有趣的性质。其中,刚性双环结构腔的固有手性和3和6位两个羟基的存在,可用于官能团相互转换,对于真正的创新应用来说,这是最有趣的特征。本文分析了从不同复杂程度的多糖和生物质中合成异己酯的策略,并从可持续性的角度讨论了传统合成路线的替代方法。其次,强调了使异山梨酯在可用性、稳定性和可扩展性方面成为最适合创新生产工艺的异己酯化合物的性质。本文对这些极为有趣的化合物的应用领域进行了研究,并从其作为构件、手性助剂或手性离子液体组分的用途方面分析了异己酯的开发领域。最后,异山梨酯作为一个单体或共聚单体广泛的不同性质的高分子材料的许多应用可能性,已被彻底研究。本综述通过分析其作为目前油基中间体的普遍替代品的开发的积极和消极方面,首次调查了基于异己烯的化合物的可能用途。当然,未来对那些占据化工产品市场很大份额的生产工艺的优化研究将导致对具有异己二酯结构的化合物的合成潜力的确认。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthetic routes and fields of application of isohexides: comprehensive perspective of relevant industrial compounds

Isohexides are a class of compounds that can be obtained from natural sources using simple processes, and have interesting properties. Among these, the intrinsic chirality of the rigid bicyclic structural cavity and the presence of two hydroxyl groups in positions 3 and 6, available for functional-group interconversion, appear the most interesting characteristics for real innovative applications. In this review, the strategies for the synthesis of isohexides from polysaccharides and biomasses of different complexities have been analyzed and the alternative processes to the traditional synthetic routes, in terms of sustainability, have been discussed. Secondly, the properties that make isosorbide the most suitable isohexide compound in terms of availability, stability and scalability for innovative production processes have been highlighted. The fields of application of these extremely interesting compounds have been investigated, proceeding with a discussion in which the areas of exploitation of isohexides are analyzed, in terms of their use as building blocks, chiral auxiliaries or constituents of chiral ionic liquids. Finally, the numerous applicative possibilities of isosorbide as a monomer or co-monomer of a wide range of polymeric materials of different natures, have been thoroughly investigated. This review represents a first investigation into the possible uses of isohexide-based compounds by analyzing the positive and negative aspects of their exploitation as ubiquitous alternatives to current oil-based intermediates. Certainly, future studies on the optimization of those production processes that occupy a large share of the chemical-product market will lead to the confirmation of the synthetic potential of compounds with an isohexidic structure.

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