Studies on Interactional Behavior of Anticoagulant Drug Aspirin in Aqueous Environments through Physicochemical and Spectroscopic Methods

A comprehensive analysis of the interactional behavior of aspirin in water is conducted by performing physicochemical, spectroscopic, and cyclic voltammetric studies. The physicochemical properties were evaluated by measuring the densities, sound speeds, conductance, and viscosity values for aqueous solutions of aspirin with varying concentrations (0.001–0.010) mol kg^–1 at four distinct temperatures (300.15–315.15) K. The experimental data was further used to calculate various physicochemical parameters. On increasing temperature, the values of Φ_v^O increased from 126.83 to 134.50 and Φ_K^O increased from −6.77 to −3.45, suggesting strong drug–water interactions. A similar trend prevailed in Φ_E^O, revealing the presence of the caging effect and structure-making behavior of aspirin. Moreover, hyperchromic shift in UV–visible spectrum, quenching in fluorescence spectra, and shift in FTIR spectrum (recorded at T/K = 298.15 and P/MPa = 0.1) strongly validate and strengthen the results of strong intermolecular interactions derived from the physicochemical data. The cyclic voltammetry technique was employed to investigate the electrochemical response of aspirin. The current investigation revealed valuable information on the stability, solubility, electrochemical properties, and intermolecular interactions of aspirin in water. The findings could be helpful, particularly in drug delivery systems, ensuring better therapeutic outcomes and making the research highly relevant for pharmaceutical applications.