n-苯基吡啶-2胺与TFISYs厌氧或好氧反应合成2- cf3 -吲哚或2- cf3 -吲哚-3-酮

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-05-13 DOI:10.1039/d5cc01652e

Miaomiao Liang , Yuanshuang Xu , Xueying Yang , Xinying Zhang , Xuesen Fan

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引用次数: 0

摘要

本文以n-苯基吡啶-2胺与三氟甲基咪甲酰亚砜酰化（TFISYs）厌氧或好氧反应为基础，在条件控制下选择性合成了2- cf3 -吲哚或2- cf3 -吲哚-3-酮。这项工作不仅揭示了TFISYs的一种新的反应模式，而且为苯胺衍生物的有效功能化提供了一个强有力的方案，从而导致具有药用特权的CF3单元的吲哚相关支架的简洁和选择性组装。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of 2-CF3-indoles or 2-CF3-indolin-3-ones via anaerobic or aerobic reactions of N-phenylpyridin-2-amines with TFISYs†

Presented herein is a condition-controlled selective synthesis of 2-CF₃-indoles or 2-CF₃-indolin-3-ones based on the anaerobic or aerobic reaction of N-phenylpyridin-2-amines with trifluoromethyl imidoyl sulfoxonium ylides (TFISYs). This work not only discloses a novel reaction mode of TFISYs, but also provides a robust protocol for the effective functionalization of aniline derivatives leading to the concise and selective assembly of indole-related scaffolds bearing a pharmaceutically privileged CF₃ unit.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.