大型性健康诊所96周多西环素暴露后预防的持续有效性：中断时间序列分析。

IF 8.2 1区医学 Q1 IMMUNOLOGY

Clinical Infectious Diseases Pub Date : 2025-05-06 DOI:10.1093/cid/ciaf234

Matthew A Spinelli,Megan J Heise,Jorge Roman,Jason Bena,Michael P Barry,Susan P Buchbinder,Hyman M Scott

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引用次数: 0

摘要

多西环素暴露后预防（doxy-PEP）降低了性健康诊所96周内细菌性传播感染（STI）的发病率(n=4,592；2524人服用doxy-PEP)，特别是对衣原体和梅毒，对淋病的效果较小。持续监测淋病和抗生素耐药性对于评估doxy-PEP的长期有效性至关重要。

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Sustained Effectiveness of Doxycycline Post-Exposure-Prophylaxis in a Large Sexual Health Clinic over 96 Weeks: An Interrupted Time Series Analysis.

Doxycycline post-exposure prophylaxis (doxy-PEP) reduced bacterial sexually transmitted infection (STI) incidence in a sexual health clinic over 96 weeks (n=4,592; 2,524 on doxy-PEP), particularly for chlamydia and syphilis, with smaller effects for gonorrhea. Continued surveillance for gonorrhea and antibiotic resistance is essential to evaluate doxy-PEP's long-term effectiveness.

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来源期刊

Clinical Infectious Diseases 医学-传染病学

CiteScore

25.00

自引率

2.50%

发文量

900

审稿时长

3 months

期刊介绍： Clinical Infectious Diseases (CID) is dedicated to publishing original research, reviews, guidelines, and perspectives with the potential to reshape clinical practice, providing clinicians with valuable insights for patient care. CID comprehensively addresses the clinical presentation, diagnosis, treatment, and prevention of a wide spectrum of infectious diseases. The journal places a high priority on the assessment of current and innovative treatments, microbiology, immunology, and policies, ensuring relevance to patient care in its commitment to advancing the field of infectious diseases.