{"title":"膀胱小细胞癌经放化疗后肿瘤明显缩小1例","authors":"Rintaro Yoshitake, Syunsuke Taguchi, Yoshimasa Harada","doi":"10.1002/iju5.70031","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Small cell carcinoma of the bladder (SCCB) is a rare and aggressive disease with no established standard treatment. We report a case of SCCB that initially progressed with chemotherapy but responded well to a combination of chemotherapy and radiotherapy.</p>\n </section>\n \n <section>\n \n <h3> Case Presentation</h3>\n \n <p>A 62-year-old man presented with painless gross hematuria. Transurethral resection of the bladder tumor (TURBT) confirmed SCCB. Gemcitabine-carboplatin (GEM-CBDCA) and pembrolizumab were ineffective, leading to rapid tumor progression. The patient developed bladder tamponade and obstructive renal failure. Emergency radiotherapy (30 Gy) controlled bleeding, and etoposide-carboplatin chemotherapy resulted in significant tumor shrinkage.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>This case highlights the potential effectiveness of etoposide-carboplatin and radiotherapy in SCCB, especially in cases resistant to other treatments. Further studies are needed to establish optimal treatment strategies for SCCB.</p>\n </section>\n </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 3","pages":"289-292"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70031","citationCount":"0","resultStr":"{\"title\":\"A Case of Small Cell Carcinoma of Bladder With Significant Tumor Reduction Following Combination Chemotherapy and Radiation Therapy\",\"authors\":\"Rintaro Yoshitake, Syunsuke Taguchi, Yoshimasa Harada\",\"doi\":\"10.1002/iju5.70031\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Small cell carcinoma of the bladder (SCCB) is a rare and aggressive disease with no established standard treatment. We report a case of SCCB that initially progressed with chemotherapy but responded well to a combination of chemotherapy and radiotherapy.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Case Presentation</h3>\\n \\n <p>A 62-year-old man presented with painless gross hematuria. Transurethral resection of the bladder tumor (TURBT) confirmed SCCB. Gemcitabine-carboplatin (GEM-CBDCA) and pembrolizumab were ineffective, leading to rapid tumor progression. The patient developed bladder tamponade and obstructive renal failure. Emergency radiotherapy (30 Gy) controlled bleeding, and etoposide-carboplatin chemotherapy resulted in significant tumor shrinkage.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>This case highlights the potential effectiveness of etoposide-carboplatin and radiotherapy in SCCB, especially in cases resistant to other treatments. Further studies are needed to establish optimal treatment strategies for SCCB.</p>\\n </section>\\n </div>\",\"PeriodicalId\":52909,\"journal\":{\"name\":\"IJU Case Reports\",\"volume\":\"8 3\",\"pages\":\"289-292\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70031\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IJU Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/iju5.70031\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IJU Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iju5.70031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
A Case of Small Cell Carcinoma of Bladder With Significant Tumor Reduction Following Combination Chemotherapy and Radiation Therapy
Introduction
Small cell carcinoma of the bladder (SCCB) is a rare and aggressive disease with no established standard treatment. We report a case of SCCB that initially progressed with chemotherapy but responded well to a combination of chemotherapy and radiotherapy.
Case Presentation
A 62-year-old man presented with painless gross hematuria. Transurethral resection of the bladder tumor (TURBT) confirmed SCCB. Gemcitabine-carboplatin (GEM-CBDCA) and pembrolizumab were ineffective, leading to rapid tumor progression. The patient developed bladder tamponade and obstructive renal failure. Emergency radiotherapy (30 Gy) controlled bleeding, and etoposide-carboplatin chemotherapy resulted in significant tumor shrinkage.
Conclusion
This case highlights the potential effectiveness of etoposide-carboplatin and radiotherapy in SCCB, especially in cases resistant to other treatments. Further studies are needed to establish optimal treatment strategies for SCCB.
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