{"title":"Waldenström右肾周肿瘤超声引导活检诊断巨球蛋白血症","authors":"Shingo Morinaga, Shigeyuki Aoki, Motoi Tobiume, Genya Nishikawa, Fusako Higuchi, Yuusuke Ikenohata, Manabu Honda, Hiroe Kubo, Tomoko Sawada, Yoshiaki Yamada","doi":"10.1002/iju5.70022","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Waldenström macroglobulinemia is a low-grade B-cell lymphoma characterized by lymphoplasmacytic lymphoma infiltration of the bone marrow and immunoglobulin M (IgM) protein.</p>\n </section>\n \n <section>\n \n <h3> Case Presentation</h3>\n \n <p>An 80s-year-old male presented to our hospital with chief complaints of weight loss and general fatigue. Computed tomography (CT) showed homogeneous tumor around the kidney with elevated soluble Interleukin-2 receptor, serum IgM, and β2-microglobulin levels. Histopathological analysis by ultrasonography-guided biopsy revealed dense lymphocytic proliferation, plasmacytoid differentiation, and Dutcher bodies, positive for CD20, CD138, and IgM, but negative for CD3 and CD5, consistent with lymphoplasmacytic lymphoma. Bone marrow biopsy revealed infiltration of the lymphoplasmacytic lymphoma. The patient received four courses of bortezomib, cyclophosphamide, and dexamethasone along with dexamethasone, rituximab, and cyclophosphamide therapy. Twelve months after treatment, CT revealed only slightly enlarged abdominal para-aortic lymph nodes.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Malignant lymphoma in perinephric lesions is a relatively rare condition; however, a definitive diagnosis can be obtained by ultrasound-guided biopsy, allowing early initiation.</p>\n </section>\n </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 3","pages":"271-275"},"PeriodicalIF":0.0000,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70022","citationCount":"0","resultStr":"{\"title\":\"Waldenström Macroglobulinemia Diagnosed by Ultrasonography-Guided Biopsy of the Right Perinephric Tumor\",\"authors\":\"Shingo Morinaga, Shigeyuki Aoki, Motoi Tobiume, Genya Nishikawa, Fusako Higuchi, Yuusuke Ikenohata, Manabu Honda, Hiroe Kubo, Tomoko Sawada, Yoshiaki Yamada\",\"doi\":\"10.1002/iju5.70022\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Waldenström macroglobulinemia is a low-grade B-cell lymphoma characterized by lymphoplasmacytic lymphoma infiltration of the bone marrow and immunoglobulin M (IgM) protein.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Case Presentation</h3>\\n \\n <p>An 80s-year-old male presented to our hospital with chief complaints of weight loss and general fatigue. Computed tomography (CT) showed homogeneous tumor around the kidney with elevated soluble Interleukin-2 receptor, serum IgM, and β2-microglobulin levels. Histopathological analysis by ultrasonography-guided biopsy revealed dense lymphocytic proliferation, plasmacytoid differentiation, and Dutcher bodies, positive for CD20, CD138, and IgM, but negative for CD3 and CD5, consistent with lymphoplasmacytic lymphoma. Bone marrow biopsy revealed infiltration of the lymphoplasmacytic lymphoma. The patient received four courses of bortezomib, cyclophosphamide, and dexamethasone along with dexamethasone, rituximab, and cyclophosphamide therapy. Twelve months after treatment, CT revealed only slightly enlarged abdominal para-aortic lymph nodes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Malignant lymphoma in perinephric lesions is a relatively rare condition; however, a definitive diagnosis can be obtained by ultrasound-guided biopsy, allowing early initiation.</p>\\n </section>\\n </div>\",\"PeriodicalId\":52909,\"journal\":{\"name\":\"IJU Case Reports\",\"volume\":\"8 3\",\"pages\":\"271-275\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-04-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70022\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IJU Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/iju5.70022\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IJU Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iju5.70022","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Waldenström Macroglobulinemia Diagnosed by Ultrasonography-Guided Biopsy of the Right Perinephric Tumor
Introduction
Waldenström macroglobulinemia is a low-grade B-cell lymphoma characterized by lymphoplasmacytic lymphoma infiltration of the bone marrow and immunoglobulin M (IgM) protein.
Case Presentation
An 80s-year-old male presented to our hospital with chief complaints of weight loss and general fatigue. Computed tomography (CT) showed homogeneous tumor around the kidney with elevated soluble Interleukin-2 receptor, serum IgM, and β2-microglobulin levels. Histopathological analysis by ultrasonography-guided biopsy revealed dense lymphocytic proliferation, plasmacytoid differentiation, and Dutcher bodies, positive for CD20, CD138, and IgM, but negative for CD3 and CD5, consistent with lymphoplasmacytic lymphoma. Bone marrow biopsy revealed infiltration of the lymphoplasmacytic lymphoma. The patient received four courses of bortezomib, cyclophosphamide, and dexamethasone along with dexamethasone, rituximab, and cyclophosphamide therapy. Twelve months after treatment, CT revealed only slightly enlarged abdominal para-aortic lymph nodes.
Conclusion
Malignant lymphoma in perinephric lesions is a relatively rare condition; however, a definitive diagnosis can be obtained by ultrasound-guided biopsy, allowing early initiation.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
