Samarpita Mahapatra, Sebastian H. Kopf, Toby Halamka, Christian Merten, Deborah A. Drost, Adriaan J. Minnaard
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引用次数: 0
摘要
brgdgtia是最常见的支链甘油二烷基甘油四醚之一，由酸杆菌产生，作为跨膜脂质。地球化学家在古环境研究中广泛使用这些方法。该图像显示了琼脂平板上的酸杆菌菌落和brGDGT Ia的结构，其甲基分支的syn构型已被阐明，这是以前未知的。A. J. Minnaard及其同事的研究文章（DOI: 10.1002/chem.202500702）描述了脂质的第一次全合成以及甲基分支的相对立体化学构型是如何确定的。
Cover Feature: Total Synthesis of the Membrane Spanning Tetraether Lipid brGDGT Ia and Elucidation of Its Stereochemical Configuration
brGDGT Ia is one of the most common branched glycerol dialkyl glycerol tetraethers produced by Acidobacteria as membrane-spanning lipids. These are used extensively by geochemists for paleoenvironmental studies. The image shows Acidobacteria colonies on an agar plate and the structure of brGDGT Ia with the elucidated syn configuration of the methyl branches, which was previously unknown. The Research Article by A. J. Minnaard and co-workers (DOI: 10.1002/chem.202500702) describes the first total synthesis of the lipid and how the relative stereochemical configuration of the methyl branches was determined.
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