早期识别视网膜征象Waldenström的大球蛋白血症：治疗血浆交换的意义

IF 1.4 4区医学 Q4 HEMATOLOGY

Journal of Clinical Apheresis Pub Date : 2025-05-07 DOI:10.1002/jca.70031

Álvaro Ponce-de-León, Alfonso Miranda-Sánchez, Alicia Valverde-Megias

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引用次数: 0

摘要

本报告强调眼科医生在推荐治疗性血浆置换（TPE）治疗系统性疾病（如Waldenström的巨球蛋白血症（WM））时的关键作用。一位疑似WM的患者接受了眼科检查，发现周围视网膜出血和罗斯斑，尽管没有视觉上的不适。眼底成像记录了这些变化，与IgM水平升高（86.32 g/L）相关，表明高黏度综合征（HVS）。早期视网膜发现促使TPE减轻HVS并发症。随后的骨髓活检证实WM伴有MYD88 L265P突变。本病例强调了眼科在指导血液学干预和改善预后方面的重要性。

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Early Recognition of Retinal Signs in Waldenström's Macroglobulinemia: Implications for Therapeutic Plasma Exchange

This report highlights the pivotal role of ophthalmologists in recommending therapeutic plasma exchange (TPE) for systemic disorders like Waldenström's macroglobulinemia (WM). A patient with suspected WM underwent ophthalmic evaluation, revealing peripheral retinal hemorrhages and Roth spots despite no visual complaints. Fundus imaging documented these changes, correlating with elevated IgM levels (86.32 g/L), indicative of hyperviscosity syndrome (HVS). Early retinal findings prompted TPE to mitigate HVS complications. Subsequent bone marrow biopsy confirmed WM with the MYD88 L265P mutation. This case underscores the importance of ophthalmologic insights in guiding hematologic interventions and improving outcomes.

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来源期刊

Journal of Clinical Apheresis 医学-血液学

CiteScore

2.80

自引率

13.30%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Clinical Apheresis publishes articles dealing with all aspects of hemapheresis. Articles welcomed for review include those reporting basic research and clinical applications of therapeutic plasma exchange, therapeutic cytapheresis, therapeutic absorption, blood component collection and transfusion, donor recruitment and safety, administration of hemapheresis centers, and innovative applications of hemapheresis technology. Experimental studies, clinical trials, case reports, and concise reviews will be welcomed.