Yizhi Feng, Xibao Wu, Qixia Sun, Yanli Bian, Lin Liang
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引用次数: 0
摘要
通过12个试验小区的田间试验,评价了氯虫腈和甲氧虫酰肼在玉米栽培系统中应用的可行性。两种农药在玉米基质中的回收率为95% ~ 106%,相对标准偏差(rsd)为1% ~ 7%。分析结果表明,在田间条件下,在28天和35天的收获间隔内,玉米籽粒和新鲜玉米样品中两种农药残留浓度均低于0.02 mg kg - 1的定量限(LOQ)。饮食风险评估显示出不同的暴露特征:在国内和国际模型中,氯虫腈的长期暴露风险为0.1%-2.3%,而甲氧虫腈的长期暴露风险较高(0.9%-17.9%)。综合牲畜日粮负担计算表明,这两种化合物在动物源性产品(包括牛奶、肌肉组织、肝脏、肾脏和脂肪)中的估计最大残留水平(EMRLs)显示出显著的安全边际。所有EMRL值都大大低于主要监管机构(食品法典委员会(CAC)、美国环境保护署(US EPA)、日本农业标准(JAS)和欧盟法规)设定的最大残留限量(MRLs)。
Safety Assessment of Chlorantraniliprole and Methoxyfenozide in Maize: Residue Analysis, Dietary Risk Evaluation, and Estimation of Residues in Animal-Derived Products
Field experiments conducted across 12 experimental plots evaluated the application feasibility of chlorantraniliprole and methoxyfenozide in maize cultivation systems. The recovery rates of two pesticides in maize matrices ranged from 95% to 106%, with relative standard deviations (RSDs) of 1%–7%. Analytical results demonstrated that residual concentrations of both pesticides in maize kernels and fresh maize samples remained below the limit of quantitation (LOQ) of 0.02 mg kg−1 during both 28-day and 35-day harvest intervals under field conditions. Dietary risk assessments demonstrated distinct exposure profiles: chlorantraniliprole exhibited long-term exposure risks of 0.1%–2.3% across domestic and international models, while methoxyfenozide showed higher quotients (0.9%–17.9%). Comprehensive livestock dietary burden calculations indicated that estimated maximum residue levels (EMRLs) for both compounds in animal-derived products including milk, muscle tissue, liver, kidney, and fat showed significant safety margins. All EMRL values were substantially lower than established maximum residue limits (MRLs) set by major regulatory bodies: the Codex Alimentarius Commission (CAC), United States Environmental Protection Agency (US EPA), Japanese Agricultural Standards (JAS), and European Union (EU) regulations.
期刊介绍:
Biomedical Chromatography is devoted to the publication of original papers on the applications of chromatography and allied techniques in the biological and medical sciences. Research papers and review articles cover the methods and techniques relevant to the separation, identification and determination of substances in biochemistry, biotechnology, molecular biology, cell biology, clinical chemistry, pharmacology and related disciplines. These include the analysis of body fluids, cells and tissues, purification of biologically important compounds, pharmaco-kinetics and sequencing methods using HPLC, GC, HPLC-MS, TLC, paper chromatography, affinity chromatography, gel filtration, electrophoresis and related techniques.