揭示植物mirna与植物次生代谢物之间的相互作用：跨王国调控机制的新前沿

IF 6.1 2区生物学 Q1 PLANT SCIENCES

Plant Physiology and Biochemistry Pub Date : 2025-04-28 DOI:10.1016/j.plaphy.2025.109965

Yamini Agarwal , Pammi Gauba , Vibha Rani

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引用次数: 0

摘要

MicroRNAs （miRNAs）也被称为具有18-24个核苷酸的单链rna，具有很强的保守性。它们代表了一类对植物细胞发育、分裂、分化、增殖和死亡至关重要的先天rna。据报道，植物源次生代谢物的药理作用有助于其治疗潜力。植物源性mirna由于积极参与这些植物次生代谢物（PSM）而引起了相当大的兴趣。psm可以通过饮食吸收，并通过外源性和内源性相互作用发挥其广泛的治疗潜力。近年来，植物mirna在哺乳动物中调控某些基因表达的发现引起了人们的广泛关注，为生物学研究中跨界调控机制的研究创造了新的机会。本文综述了mirna在植物中的作用，重点讨论了跨界的psm。目的是基于植物miRNA参与次生代谢物并作为跨界基因调控的转移分子，提供一个概念性的理论框架。植物mirna的多种表达模式和影响多种生理和发育过程的能力使它们成为推进临床前研究的有希望的候选者。

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Unravelling the interplay between plant miRNAs and plant secondary metabolites: A new frontier in cross- kingdom regulatory mechanisms

MicroRNAs (miRNAs) are also known as single-stranded RNAs with 18–24 nucleotides and exhibit substantial conservation. They represent a class of innate RNAs that are essential for plant cell development, division, differentiation, proliferation, and death. The reported pharmacological effects of plant-derived secondary metabolites contribute to their therapeutic potential. Plant-derived miRNAs have drawn considerable interest as a result of their active involvement in these plant secondary metabolites (PSM). PSMs can be absorbed via diet, and exert a wide range of their therapeutic potential, via exogenous and endogenous interactions. The recent identification of plant miRNAs in controlling the expression of certain genes in mammals has attracted a lot of attention and created new opportunities for studying cross-kingdom regulatory mechanisms in biological research. This review discusses the role of miRNAs in plants, with focus on PSMs via cross-kingdom. The aim is to provide a conceptual theoretical framework based on the involvement of plant miRNA with secondary metabolites and being used as a transfer molecule for cross-kingdom gene regulation. Plant miRNAs' diverse expression patterns and ability to affect several physiological and developmental processes make them promising candidates for advancing preclinical research.

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来源期刊

Plant Physiology and Biochemistry 生物-植物科学

CiteScore

11.10

自引率

3.10%

发文量

410

审稿时长

33 days

期刊介绍： Plant Physiology and Biochemistry publishes original theoretical, experimental and technical contributions in the various fields of plant physiology (biochemistry, physiology, structure, genetics, plant-microbe interactions, etc.) at diverse levels of integration (molecular, subcellular, cellular, organ, whole plant, environmental). Opinions expressed in the journal are the sole responsibility of the authors and publication does not imply the editors'' agreement. Manuscripts describing molecular-genetic and/or gene expression data that are not integrated with biochemical analysis and/or actual measurements of plant physiological processes are not suitable for PPB. Also "Omics" studies (transcriptomics, proteomics, metabolomics, etc.) reporting descriptive analysis without an element of functional validation assays, will not be considered. Similarly, applied agronomic or phytochemical studies that generate no new, fundamental insights in plant physiological and/or biochemical processes are not suitable for publication in PPB. Plant Physiology and Biochemistry publishes several types of articles: Reviews, Papers and Short Papers. Articles for Reviews are either invited by the editor or proposed by the authors for the editor''s prior agreement. Reviews should not exceed 40 typewritten pages and Short Papers no more than approximately 8 typewritten pages. The fundamental character of Plant Physiology and Biochemistry remains that of a journal for original results.