成人耐药和新诊断癫痫患者的听觉P300事件相关电位和认知功能

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES

Epilepsy & Behavior Pub Date : 2025-05-06 DOI:10.1016/j.yebeh.2025.110431

Athira S.B , Pravati Pal , Pradeep P Nair , Rajeswari Aghoram , Nivedita Nanda

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引用次数: 0

摘要

目的癫痫相关的认知障碍影响多个认知领域。我们旨在评估与对照组相比，耐药癫痫（DRE）和新诊断癫痫（NDE）患者的认知功能及其影响因素。方法对DRE （n = 88）、NDE （n = 88）和健康对照（n = 88）的成人进行听觉事件相关电位P300、蒙特利尔认知评估（MoCA）、额叶评估电池（FAB）和手指广度的测试。对数据进行了分析和比较。结果我们发现潜伏期明显延长(p <；0.001)和减小幅度(p <；与对照组相比，DRE和NDE患者P300的差异为0.001)。MoCA、FAB和指距得分显著低于对照组(p <；与对照组相比，DRE和NDE的差异为0.001)。与NDE相比，DRE的P300潜伏期更大，得分明显更低。总发作次数与NDE患者MOCA （p = 0.03）、FAB （p = 0.04）、后指距（p = 0.008）呈负相关。结论与对照组相比，DRE和NDE患者的认知能力下降，且DRE患者的认知能力下降更明显。不受控制的癫痫发作和综合治疗加重癫痫患者的认知障碍。

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Auditory P300 event related potential and cognitive function in adults with drug resistant and newly diagnosed epilepsy

Objective

Cognitive impairment associated with epilepsy affects multiple domains of cognition. We aimed to assess the cognitive function and factors affecting cognition in drug resistant epilepsy (DRE) and newly diagnosed epilepsy (NDE), compared to controls.

Methods

In adults with DRE (n = 88), NDE (n = 88) and healthy controls (n = 88), auditory event-related potential P300, Montreal cognitive assessment (MoCA), frontal assessment battery (FAB) and digit span were assessed. The data was analyzed and compared across the groups.

Results

We found a significantly prolonged latency (p < 0.001) and reduced amplitude (p < 0.001) of P300 in DRE and NDE compared to controls. The scores of MoCA, FAB and digit span were significantly low (p < 0.001) in DRE and NDE compared to controls. Also, the P300 latency was greater, and the scores were significantly lower in DRE compared to NDE. The total seizure episode was negatively associated with MOCA (p = 0.03), FAB (p = 0.04), and backward digit span (p = 0.008) in NDE.

Conclusions

Cognitive performance was reduced in individuals with DRE and NDE compared to controls and this impairment was more for the DRE. Uncontrolled seizures and polytherapy worsen cognitive impairment in people with epilepsy.

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.