Shujun Cao, Peihong Ji, Rongjian Ding, Hao Xia, Hongli Mao* and Zhongwei Gu,
{"title":"绿色高效制备原位合成氧化锌壳聚糖基海绵用于深度创伤出血和伤口愈合","authors":"Shujun Cao, Peihong Ji, Rongjian Ding, Hao Xia, Hongli Mao* and Zhongwei Gu, ","doi":"10.1021/acsami.5c0419510.1021/acsami.5c04195","DOIUrl":null,"url":null,"abstract":"<p >Deep trauma often leads to acute bleeding and infections, which are major causes of death. It is worth exploring the preparation of hemostatic materials and improving their hemostatic and antibacterial properties applied to deep trauma by green and efficient methods. In this study, porous chitosan/zinc oxide/alkylated chitosan (CS/ZnO/ACS) sponges were prepared by a freezing phase separation method. ACS induced the formation of stable foam, increasing the pore formation during the freezing phase separation process. The porous structure enabled the sponge to rapidly absorb blood and expand to close the wound. The <i>in situ</i> synthesis of ZnO within the sponge enhances its antibacterial properties. In the antibacterial test against <i>S. aureus</i> and <i>E. coli</i>, the CS/ZnO/ACS sponges can effectively inhibit bacterial growth. Besides, compared with CS sponges, the introduction of ACS increases the adhesion of the CS/ZnO/ACS sponges to blood cells and promotes coagulation. In addition, the CS/ZnO/ACS sponges were prepared by physical phase separation, which endows it with increased solubility under acidic conditions and can be quickly removed after hemostasis. Therefore, the CS/ZnO/ACS expandable sponges offer promising clinical applications for the treatment of deep trauma.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":"17 18","pages":"26455–26466 26455–26466"},"PeriodicalIF":8.2000,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Green and Efficient Preparation of Chitosan-Based Sponge with In Situ Synthesized ZnO for Deep Trauma Bleeding and Wound Healing\",\"authors\":\"Shujun Cao, Peihong Ji, Rongjian Ding, Hao Xia, Hongli Mao* and Zhongwei Gu, \",\"doi\":\"10.1021/acsami.5c0419510.1021/acsami.5c04195\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Deep trauma often leads to acute bleeding and infections, which are major causes of death. It is worth exploring the preparation of hemostatic materials and improving their hemostatic and antibacterial properties applied to deep trauma by green and efficient methods. In this study, porous chitosan/zinc oxide/alkylated chitosan (CS/ZnO/ACS) sponges were prepared by a freezing phase separation method. ACS induced the formation of stable foam, increasing the pore formation during the freezing phase separation process. The porous structure enabled the sponge to rapidly absorb blood and expand to close the wound. The <i>in situ</i> synthesis of ZnO within the sponge enhances its antibacterial properties. In the antibacterial test against <i>S. aureus</i> and <i>E. coli</i>, the CS/ZnO/ACS sponges can effectively inhibit bacterial growth. Besides, compared with CS sponges, the introduction of ACS increases the adhesion of the CS/ZnO/ACS sponges to blood cells and promotes coagulation. In addition, the CS/ZnO/ACS sponges were prepared by physical phase separation, which endows it with increased solubility under acidic conditions and can be quickly removed after hemostasis. Therefore, the CS/ZnO/ACS expandable sponges offer promising clinical applications for the treatment of deep trauma.</p>\",\"PeriodicalId\":5,\"journal\":{\"name\":\"ACS Applied Materials & Interfaces\",\"volume\":\"17 18\",\"pages\":\"26455–26466 26455–26466\"},\"PeriodicalIF\":8.2000,\"publicationDate\":\"2025-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Materials & Interfaces\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsami.5c04195\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Materials & Interfaces","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsami.5c04195","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Green and Efficient Preparation of Chitosan-Based Sponge with In Situ Synthesized ZnO for Deep Trauma Bleeding and Wound Healing
Deep trauma often leads to acute bleeding and infections, which are major causes of death. It is worth exploring the preparation of hemostatic materials and improving their hemostatic and antibacterial properties applied to deep trauma by green and efficient methods. In this study, porous chitosan/zinc oxide/alkylated chitosan (CS/ZnO/ACS) sponges were prepared by a freezing phase separation method. ACS induced the formation of stable foam, increasing the pore formation during the freezing phase separation process. The porous structure enabled the sponge to rapidly absorb blood and expand to close the wound. The in situ synthesis of ZnO within the sponge enhances its antibacterial properties. In the antibacterial test against S. aureus and E. coli, the CS/ZnO/ACS sponges can effectively inhibit bacterial growth. Besides, compared with CS sponges, the introduction of ACS increases the adhesion of the CS/ZnO/ACS sponges to blood cells and promotes coagulation. In addition, the CS/ZnO/ACS sponges were prepared by physical phase separation, which endows it with increased solubility under acidic conditions and can be quickly removed after hemostasis. Therefore, the CS/ZnO/ACS expandable sponges offer promising clinical applications for the treatment of deep trauma.
期刊介绍:
ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.