绿色高效制备原位合成氧化锌壳聚糖基海绵用于深度创伤出血和伤口愈合

IF 8.2 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Shujun Cao, Peihong Ji, Rongjian Ding, Hao Xia, Hongli Mao* and Zhongwei Gu, 
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引用次数: 0

摘要

深度创伤往往导致急性出血和感染,这是死亡的主要原因。采用绿色高效的方法制备止血材料,提高其应用于深部创伤的止血和抗菌性能是值得探索的。本研究采用冷冻相分离法制备了多孔壳聚糖/氧化锌/烷基化壳聚糖(CS/ZnO/ACS)海绵。ACS诱导稳定泡沫的形成,增加了冻结相分离过程中孔隙的形成。多孔结构使海绵能够迅速吸收血液并膨胀以闭合伤口。在海绵中原位合成氧化锌,提高了海绵的抗菌性能。在对金黄色葡萄球菌和大肠杆菌的抑菌试验中,CS/ZnO/ACS海绵能有效抑制细菌的生长。此外,与CS海绵相比,ACS的引入增加了CS/ZnO/ACS海绵对血细胞的粘附,促进了凝血。此外,采用物理相分离法制备CS/ZnO/ACS海绵,使其在酸性条件下的溶解度提高,止血后可快速去除。因此,CS/ZnO/ACS可膨胀海绵在治疗深部创伤方面具有广阔的临床应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Green and Efficient Preparation of Chitosan-Based Sponge with In Situ Synthesized ZnO for Deep Trauma Bleeding and Wound Healing

Green and Efficient Preparation of Chitosan-Based Sponge with In Situ Synthesized ZnO for Deep Trauma Bleeding and Wound Healing

Deep trauma often leads to acute bleeding and infections, which are major causes of death. It is worth exploring the preparation of hemostatic materials and improving their hemostatic and antibacterial properties applied to deep trauma by green and efficient methods. In this study, porous chitosan/zinc oxide/alkylated chitosan (CS/ZnO/ACS) sponges were prepared by a freezing phase separation method. ACS induced the formation of stable foam, increasing the pore formation during the freezing phase separation process. The porous structure enabled the sponge to rapidly absorb blood and expand to close the wound. The in situ synthesis of ZnO within the sponge enhances its antibacterial properties. In the antibacterial test against S. aureus and E. coli, the CS/ZnO/ACS sponges can effectively inhibit bacterial growth. Besides, compared with CS sponges, the introduction of ACS increases the adhesion of the CS/ZnO/ACS sponges to blood cells and promotes coagulation. In addition, the CS/ZnO/ACS sponges were prepared by physical phase separation, which endows it with increased solubility under acidic conditions and can be quickly removed after hemostasis. Therefore, the CS/ZnO/ACS expandable sponges offer promising clinical applications for the treatment of deep trauma.

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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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