纤维素三（3,5-二甲基苯基氨基甲酸酯）修饰的介孔中空聚合物微球对萘普生异构体的手性识别

IF 3.6 3区化学 Q2 CHEMISTRY, ANALYTICAL

Analyst Pub Date : 2025-05-06 DOI:10.1039/d5an00408j

Nan Shi, Shuyu Li, Laidi Xu, Junyao Li, Wenrong Cai, Datong Wu, Yong Kong

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引用次数: 0

摘要

以纤维素三（3,5-二甲基苯基氨基甲酸酯）（CDMPC）对介孔中空聚合物微球（M-HPMs）进行修饰，所得的手性中空聚合物微球（C-HPMs）用于萘普生（NPX）异构体的光谱手性鉴别。由于CDMPC的固有手性和M-HPMs的介孔结构，NPX异构体被C-HPMs吸附后在紫外光谱上的吸光度有显著差异。对吸附时间、CDMPC与M-HPMs的质量比、NPX浓度等参数进行了优化，以达到对NPX异构体的最高识别效率。与羧甲基纤维素钠修饰的M-HPMs和CDMPC直接修饰的中空聚合物微球（HPMs）相比，C-HPMs对NPX异构体的识别效率更高。

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Spectroscopic chiral discrimination of naproxen isomers with cellulose tris(3,5-dimethylphenylcarbamate) modified mesoporous hollow polymer microspheres

Mesoporous hollow polymer microspheres (M-HPMs) are modified with cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC), and the obtained chiral hollow polymer microspheres (C-HPMs) are utilized for the spectroscopic chiral discrimination of naproxen (NPX) isomers. Thanks to the intrinsic chirality of CDMPC and the mesoporous structure of M-HPMs, the NPX isomers exhibit significant differences in their absorbances on the ultraviolet (UV) spectra after being adsorbed by the C-HPMs. Several parameters including adsorption time, mass ratio of CDMPC to M-HPMs, and NPX concentration are optimized to achieve the highest discrimination efficiency for the NPX isomers. Compared with the M-HPMs modified with sodium carboxymethyl cellulose and the hollow polymer microspheres (HPMs) directly modified with CDMPC, the C-HPMs show higher discrimination efficiency for the NPX isomers.

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