StructMAn 2.0 Web：用于蛋白质序列和突变的结构注释的Web服务器

IF 13.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleic Acids Research Pub Date : 2025-05-06 DOI:10.1093/nar/gkaf381

Alper Yurtseven, Sebastian Keller, Pascal Hirsch, Olga V Kalinina, Alexander Gress

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引用次数: 0

摘要

StructMAn是一种蛋白质结构标注方法。它根据蛋白质的三维（3D）结构及其与其他分子的相互作用的重要性来描述蛋白质序列的每个位置或其中的特定变体。对于任何给定的蛋白质序列和/或其突变组合，StructMAn可以从实验解决和预测的蛋白质及其同源物的3D结构中绘制、比对和汇总数据。结果提供了每个氨基酸位置的结构注释，允许进行详细的结构分析。此外，StructMAn能够生成各种位置特定的高质量结构特征，可以在机器学习应用中加以利用。随着新的web服务器StructMAn 2.0 web，我们提供了一种用户友好的方式来使用StructMAn，提供了一个易于使用的输入界面和StructMAn的各种结果的全面可视化。StructMAn 2.0 Web可从https://tools.helmholtz-hips.de/structman获得。

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StructMAn 2.0 Web: a web server for structural annotation of protein sequences and mutations

StructMAn is a method for protein structural annotation. It describes each position of a protein sequence or specific variants in it in terms of their importance for the three-dimensional (3D) structure of the protein and its interactions with other molecules. StructMAn maps, aligns, and aggregates data from experimentally resolved and predicted 3D structures of proteins and their homologs for any given protein sequence and/or a combination of mutations in it. The results provide structural annotation for every amino acid position allowing a detailed structural analysis. Furthermore, StructMAn enables generation of a wide variety of position-specific high-quality structural features that can be leveraged in machine learning applications. With the new web server StructMAn 2.0 Web, we provide a user-friendly way to use StructMAn offering an easy-to-use input interface and a comprehensive visualization for the various results of StructMAn. StructMAn 2.0 Web is available at https://tools.helmholtz-hips.de/structman.

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来源期刊

Nucleic Acids Research 生物-生化与分子生物学

CiteScore

27.10

自引率

4.70%

发文量

1057

审稿时长

2 months

期刊介绍： Nucleic Acids Research (NAR) is a scientific journal that publishes research on various aspects of nucleic acids and proteins involved in nucleic acid metabolism and interactions. It covers areas such as chemistry and synthetic biology, computational biology, gene regulation, chromatin and epigenetics, genome integrity, repair and replication, genomics, molecular biology, nucleic acid enzymes, RNA, and structural biology. The journal also includes a Survey and Summary section for brief reviews. Additionally, each year, the first issue is dedicated to biological databases, and an issue in July focuses on web-based software resources for the biological community. Nucleic Acids Research is indexed by several services including Abstracts on Hygiene and Communicable Diseases, Animal Breeding Abstracts, Agricultural Engineering Abstracts, Agbiotech News and Information, BIOSIS Previews, CAB Abstracts, and EMBASE.