网络游戏障碍中动态功能网络中基于时间变异性的变化

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-04-29 DOI:10.1016/j.jpsychires.2025.04.050

Jiejie Fu , Shuaiyu Chen , Min Wang , Debo Dong , Guang-Heng Dong

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引用次数: 0

摘要

以往关于网络游戏障碍（IGD）静息状态功能连接（FC）的研究通常假设整个扫描过程中FC是静态的，而忽略了大脑网络的动态重组。然而，了解功能网络的动态变化对于全面了解IGD这一复杂且不断发展的疾病至关重要。方法收集269名参与者的静息状态fMRI数据，其中IGD受试者132名，男/女：72/60，休闲游戏用户（rgu） 137名，男/女：85/52。在网络层面（网络内和网络间），计算每组的时间变异性指数，并进行独立样本t检验。结果与rgu相比，IGD个体默认模式网络（DMN）的网络内变异性降低，腹侧注意网络（VAN）的网络内时间变异性增加，感觉运动网络（SMN）和VAN、SMN和边缘网络（LN）、VAN和LN的网络间时间变异性增加。结论IGD参与者在网络水平上的时间变异性发生变化，表明执行抑制功能和注意力受损，以及感觉-注意、感觉-情绪和情绪-动机功能之间的失衡。这些发现为IGD中大脑的动态功能组织提供了新的见解，有助于我们理解病理性游戏行为的神经基础。

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Temporal variability-based alternations in dynamic functional networks in internet gaming disorder

Background

Previous studies on resting-state functional connectivity (FC) in internet gaming disorder (IGD) have typically assumed that FC is static during the entire scan, neglecting the dynamic reorganization of brain networks. However, understanding the dynamic changes in functional networks is crucial for a comprehensive understanding of IGD, a complex and evolving disorder.

Methods

Resting-state fMRI data were collected from 269 participants (132 IGD subjects, male/female: 72/60, and 137 recreational game users (RGUs), male/female: 85/52). At the network level (within-network and between-network), temporal variability indices were calculated for each group and subjected to independent samples t-tests.

Results

Compared to RGUs, IGD individuals exhibited decreased within-network variability in the default mode network (DMN), increased within-network temporal variability in the ventral attention network (VAN), and increased between-network temporal variability in sensorimotor network (SMN) and VAN, SMN and limbic network (LN), VAN and LN.

Conclusions

Changes in temporal variability at the network level occur in participants with IGD, indicating impaired executive inhibitory functions and attention, as well as imbalances between sensory-attention, sensory-emotion, and emotion-motivation functions. These findings provide new insights into the dynamic functional organization of the brain in IGD, contributing to our understanding the neural basis of pathological gaming behaviors.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;