人偏肺病毒（hMPV）研究进展综述：结构、功能和治疗机会

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2025-05-01 DOI:10.1016/j.drudis.2025.104364

Nadine Krüger , Stefan A. Laufer , Thanigaimalai Pillaiyar

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引用次数: 0

摘要

人偏肺病毒（hMPV）是肺炎病毒科的一员，是一种重要的呼吸道病原体，可在婴儿、儿童、老年人、患有慢性疾病的成年人和免疫功能低下的个体中引起严重感染。在全球范围内，人乳头状病毒被认为是五岁以下儿童毛细支气管炎和肺炎的第二大原因。缺乏针对hMPV的靶向抗病毒治疗或疫苗使全球卫生保健系统严重紧张。本文通过回顾目前关于hMPV的生命周期、结构、功能、预防和治疗方案的文献，总结了hMPV的最新进展和科学发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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An overview of progress in human metapneumovirus (hMPV) research: Structure, function, and therapeutic opportunities

The human metapneumovirus (hMPV), a member of the Pneumoviridae family, is a significant respiratory pathogen that causes severe infections in infants, children, the elderly, adults with chronic illnesses, and individuals with immunocompromised conditions. Globally, hMPV is recognized as the second leading cause of bronchiolitis and pneumonia among children under five. The absence of targeted antiviral treatments or vaccines for hMPV significantly strains the global health-care system. This review summarizes recent advances and scientific findings on hMPV by reviewing the current literature on its life cycle, structure, function, prevention, and treatment options.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.