流动中的干性：用多模式方法解剖肠隐窝组织

IF 10.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-05-05 DOI:10.1016/j.devcel.2025.04.003

Maria Azkanaz, Dimitrios Laskaris, Jacco van Rheenen

引用次数: 0

摘要

在这一期的《发育细胞》中，Banjac等人整合了谱系追踪、单细胞RNA测序和数学模型，揭示了隐窝基部的干细胞驱动了分泌和吸收谱系承诺之间的决定。他们的发现强调了隐窝底Lgr5+细胞在维持肠上皮稳态中的核心作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Stemness in flux: Dissecting intestinal crypt organization with multimodal approaches

In this issue of Developmental Cell, Banjac et al. integrate lineage tracing, single-cell RNA sequencing, and mathematical modeling to reveal that stem cells at the crypt base drive the decision between secretory and absorptive lineage commitment. Their findings highlight the central role of crypt-bottom Lgr5⁺ cells in maintaining intestinal epithelium homeostasis.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.