在母体到合子的转变过程中卵裂期胚胎停止的人类特异性贡献者

IF 10.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-05-05 DOI:10.1016/j.devcel.2025.04.007

Mehmet-Yunus Comar, Bernardo Oldak, Jacob H. Hanna

引用次数: 0

摘要

理解早期人类胚胎发育过程中母体到合子转变（MZT）的功能调控景观仍然是一个挑战。在本期的《发育细胞》中，Guo等人评估了人类着床前胚胎的单细胞等位基因特异性转录组学，发现DPRX和ARGFX基因是阻碍卵裂期胚胎停滞的关键因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Human-specific contributors to cleavage-stage embryonic arrest during maternal to zygotic transition

Understanding the functional regulatory landscape of maternal-to-zygotic transition (MZT) during early human embryo development remains a challenge. In this issue of Developmental Cell, Guo et al. assessed single-cell allele-specific transcriptomics from human preimplantation embryos and identified DPRX and ARGFX genes as pivotal factors whose hampered activation underlies cleavage-stage embryonic arrest.

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.