深海来源的柑橘青霉W23揭示的二聚体柑橘蛋白多样性

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-05-02 DOI:10.1016/j.phytochem.2025.114532

Tai-Zong Wu , Zhi-Hui He , Cheng-You Lin , You Li , Zheng-Biao Zou , Chun-Lan Xie , Tian-Hua Zhong , Xian-Wen Yang

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引用次数: 0

摘要

对一种深海衍生真菌——柑橘青霉W23的化学研究，产生了五种以前未描述的（1-5）和一种已知的(6)二聚体柑橘霉素衍生物。它们的结构是通过广泛的光谱分析，DFT计算和生物遗传学考虑来阐明的。化合物1-6在两个单体单元之间表现出不同的连接模式，其中4-5是具有C8 ‘ -O-C6-C7-C10 ’连接的柑桔素二聚体的第一个例子。本研究扩展了柑橘霉素衍生物的多样性，并强调了基于giao的核磁共振计算在区分相似的构象异构体方面的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Dimeric citrinins diversity revealed by the deep-sea-derived Penicillium citrinum W23

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Dimeric citrinins diversity revealed by the deep-sea-derived Penicillium citrinum W23

The chemical investigation of a deep-sea-derived fungus, Penicillium citrinum W23, yielded five previously undescribed (1–5) and one known (6) dimeric citrinin derivatives. Their structures were elucidated through extensive spectroscopic analysis, DFT calculations and biogenetic considerations. Compounds 1–6 exhibited diverse connectivity patterns between the two monomeric units with 4–5 being the first exemplars of citrinin dimers featuring a C8′-O-C6-C7-C10′ linkage. This study expands the diversity of citrinin derivatives and highlights the power of GIAO-based NMR calculation in distinguishing closely resembling constitutional isomers.

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.