Mark Tawfik , Angelica Rozenfeld , Chloé Lahoud , Sumeyye Ozer , Omer Alomari , Vincent DeChavez
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PD-1 inhibitor‐induced cytomegalovirus esophagitis in a patient with metastatic urothelial carcinoma: A case report
Introduction
Immune checkpoint inhibitors (ICIs), such as Pembrolizumab, have revolutionized cancer treatment. However, they pose challenges, specifically in the form of immune-related adverse events (irAEs). Although cases of gastrointestinal irAEs have been well-documented, the occurrence of cytomegalovirus (CMV) esophagitis months after immunotherapy discontinuation, has not been well reported.
Case presentation
We report a case of immune-related CMV esophagitis three months after discontinuing pembrolizumab therapy, which had been administered for metastatic urothelial cancer.
Conclusion
IrAE and their timing remain a challenge in patients receiving ICI therapy. CMV esophagitis is a rare irAE associated with ICIs and further investigation is needed to better develop effective treatment and prevention strategies.
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